Beschreibung:
AbstractHuman pluripotent stem cells can be differentiated into the pancreatic lineage, providing a human pancreas model to study diseases and development. We improved the differentiation protocol to generate pancreatic progenitors, the common ancestor of the endocrine and exocrine pancreas. We classified the glycoprotein-2 high-expressing subpopulation as truly multipotent, thereby making it particularly suitable to engineer acinar cells. Its capability of developing simultaneously into endocrine, ductal and acinar lineages qualifies it as a useful tool for pancreatic disease modelling.