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Kretschmer, Alina Chloé; Junker, Lena; Dewald, Felix; Linne, Viktoria; Hennen, Lea; Horemheb-Rubio, Gibran; Kaiser, Rolf; Steger, Gertrud; Joachim, Alexander; Schönenkorb, Jana; Cosgun, Zülfü Cem; Mühlhans, Neslihan; Heger, Eva; Knops, Elena; Leisse, Charlotte; Kessel, Barbora; Heinsohn, Torben; Rodiah, Isti; Lange, Berit; Ritter, Anne Lena; Fries, Mira; Kossow, Annelene; Nießen, Johannes; Dötsch, Jörg; [...]

Implementing the Lolli-Method and pooled RT-qPCR testing for SARS-CoV-2 surveillance in schools: a pilot project

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  • Medientyp: E-Artikel
  • Titel: Implementing the Lolli-Method and pooled RT-qPCR testing for SARS-CoV-2 surveillance in schools: a pilot project
  • Beteiligte: Kretschmer, Alina Chloé; Junker, Lena; Dewald, Felix; Linne, Viktoria; Hennen, Lea; Horemheb-Rubio, Gibran; Kaiser, Rolf; Steger, Gertrud; Joachim, Alexander; Schönenkorb, Jana; Cosgun, Zülfü Cem; Mühlhans, Neslihan; Heger, Eva; Knops, Elena; Leisse, Charlotte; Kessel, Barbora; Heinsohn, Torben; Rodiah, Isti; Lange, Berit; Ritter, Anne Lena; Fries, Mira; Kossow, Annelene; Nießen, Johannes; Dötsch, Jörg; [...]
  • Erschienen: Springer Science and Business Media LLC, 2023
  • Erschienen in: Infection
  • Sprache: Englisch
  • DOI: 10.1007/s15010-022-01865-0
  • ISSN: 0300-8126; 1439-0973
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose</jats:title> <jats:p>School closures have been used as part of lockdown strategies to contain the spread of SARS-CoV-2, adversely affecting children’s health and education. To ensure the accessibility of educational institutions without exposing society to the risk of increased transmissions, it is essential to establish SARS-CoV-2 testing strategies that are child-friendly, scalable and implementable in a daily school routine. Self-sampling using non-invasive saliva swabs combined with pooled RT-qPCR testing (Lolli-Method) has been proven to be a sensitive method for the detection of SARS-CoV-2.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>We conducted a pilot project in Cologne, Germany, designed to determine the feasibility of a large-scale rollout of the Lolli-Method for testing without any additional on-site medical staff in schools. Over a period of three weeks, students from 22 schools were sampled using the Lolli-Method. At the end of the project, teachers were asked to evaluate the overall acceptance of the project.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>We analyzed a total of 757 pooled RT-qPCRs obtained from 8,287 individual swabs and detected 7 SARS-CoV-2 infected individuals. The Lolli-Method was shown to be a feasible and accepted testing strategy whose application is only slightly disruptive to the daily school routine.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Our observations suggest that the Lolli-Method in combination with pooled RT-qPCR can be implemented for SARS-CoV-2 surveillance in daily school routine, applicable on a large scale.</jats:p> </jats:sec>