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Giszas, Benjamin; Trommer, Sabine; Schüßler, Nane; Rodewald, Andrea; Besteher, Bianca; Bleidorn, Jutta; Dickmann, Petra; Finke, Kathrin; Katzer, Katrin; Lehmann-Pohl, Katja; Lemhöfer, Christina; Pletz, Mathias W.; Puta, Christian; Quickert, Stefanie; Walter, Martin; Stallmach, Andreas; Reuken, Philipp Alexander

Post-COVID-19 condition is not only a question of persistent symptoms: structured screening including health-related quality of life reveals two separate clusters of post-COVID

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  • Medientyp: E-Artikel
  • Titel: Post-COVID-19 condition is not only a question of persistent symptoms: structured screening including health-related quality of life reveals two separate clusters of post-COVID
  • Beteiligte: Giszas, Benjamin; Trommer, Sabine; Schüßler, Nane; Rodewald, Andrea; Besteher, Bianca; Bleidorn, Jutta; Dickmann, Petra; Finke, Kathrin; Katzer, Katrin; Lehmann-Pohl, Katja; Lemhöfer, Christina; Pletz, Mathias W.; Puta, Christian; Quickert, Stefanie; Walter, Martin; Stallmach, Andreas; Reuken, Philipp Alexander
  • Erschienen: Springer Science and Business Media LLC, 2023
  • Erschienen in: Infection
  • Sprache: Englisch
  • DOI: 10.1007/s15010-022-01886-9
  • ISSN: 0300-8126; 1439-0973
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose</jats:title> <jats:p>Some patients experience long-term sequelae after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, despite a present post-COVID condition, defined as “any symptom lasting longer than 12 weeks,” only a subset of patients search for medical help and therapy.</jats:p> </jats:sec><jats:sec> <jats:title>Method</jats:title> <jats:p>We invited all adults with a positive real-time polymerase chain reaction (RT-PCR) for SARS-CoV-2 between March 2020 and September 2021 (<jats:italic>n</jats:italic> = 4091) in the city of Jena to answer a standardized questionnaire including demographic information, the course of the acute infection and current health status. K-means-clustering of quality of life (QoL) was used to explore post-COVID subgroups.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>A total of 909 participants at a median interval of 367 (IQR 291/403) days after acute infection were included in the analysis. Of those, 643 (70.7%) complained of having experienced persistent symptoms at the time of the survey. Cluster analysis based on QoL revealed two subgroups of people with persistent post-COVID symptoms. Whereas 189/643 participants (29.4%) showed markedly diminished QoL, normal QoL was detected in 454/643 individuals (70.6%).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Despite persistent symptoms being reported by nearly three quarters of participants, only one-third of these described a significant reduction in QoL (cluster 1), whereas the other two-thirds reported a near-normal QoL (cluster 2), thus indicating a differentiation between “post-COVID disease” and “post-COVID condition”. The prevalence of clinically relevant post-COVID disease was at least 20.7%. Health policies should focus on this subset.</jats:p> </jats:sec>