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Stoliaroff-Pepin, Anna; Peine, Caroline; Herath, Tim; Lachmann, Johannes; Hellenbrand, Wiebke; Perriat, Delphine; Dörre, Achim; Nitsche, Andreas; Michel, Janine; Grossegesse, Marica; Hofmann, Natalie; Rinner, Thomas; Kohl, Claudia; Brinkmann, Annika; Meyer, Tanja; Stern, Daniel; Treindl, Fridolin; Dorner, Brigitte G.; Hein, Sascha; Werel, Laura; Hildt, Eberhard; Gläser, Sven; Schühlen, Helmut; Isner, Caroline; [...]

Vaccine effectiveness against severe COVID-19 during the Omicron wave in Germany: results from the COViK study

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  • Medientyp: E-Artikel
  • Titel: Vaccine effectiveness against severe COVID-19 during the Omicron wave in Germany: results from the COViK study
  • Beteiligte: Stoliaroff-Pepin, Anna; Peine, Caroline; Herath, Tim; Lachmann, Johannes; Hellenbrand, Wiebke; Perriat, Delphine; Dörre, Achim; Nitsche, Andreas; Michel, Janine; Grossegesse, Marica; Hofmann, Natalie; Rinner, Thomas; Kohl, Claudia; Brinkmann, Annika; Meyer, Tanja; Stern, Daniel; Treindl, Fridolin; Dorner, Brigitte G.; Hein, Sascha; Werel, Laura; Hildt, Eberhard; Gläser, Sven; Schühlen, Helmut; Isner, Caroline; [...]
  • Erschienen: Springer Science and Business Media LLC, 2023
  • Erschienen in: Infection, 51 (2023) 4, Seite 1093-1102
  • Sprache: Englisch
  • DOI: 10.1007/s15010-023-02012-z
  • ISSN: 0300-8126; 1439-0973
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Abstract Purpose COViK, a prospective hospital-based multicenter case-control study in Germany, aims to assess the effectiveness of COVID-19 vaccines against severe disease. Here, we report vaccine effectiveness (VE) against COVID-19-caused hospitalization and intensive care treatment during the Omicron wave. Methods We analyzed data from 276 cases with COVID-19 and 494 control patients recruited in 13 hospitals from 1 December 2021 to 5 September 2022. We calculated crude and confounder-adjusted VE estimates. Results 21% of cases (57/276) were not vaccinated, compared to 5% of controls (26/494; p < 0.001). Confounder-adjusted VE against COVID-19-caused hospitalization was 55.4% (95% CI: 12–78%), 81.5% (95% CI: 68–90%) and 95.6% (95%CI: 88–99%) after two, three and four vaccine doses, respectively. VE against hospitalization due to COVID-19 remained stable up to one year after three vaccine doses. Conclusion Three vaccine doses remained highly effective in preventing severe disease and this protection was sustained; a fourth dose further increased protection.