Erschienen in:
FEBS Letters, 176 (1984) 2, Seite 479-483
Sprache:
Englisch
DOI:
10.1016/0014-5793(84)81222-3
ISSN:
0014-5793;
1873-3468
Entstehung:
Anmerkungen:
Beschreibung:
Casein kinase II (CKII) activity is enhanced as much as 2–3 fold in established and 4–5‐fold in transformed human cell lines when compared to that of fibroblasts and primary human tumour cell cultures where CKII activity never exceeded a basic level. The high activity of CKII in transformed cells and in established cell lines was reduced to about the same basic level after treatment with heparin, a highly specific inhibitor of CKII activity. The activity of the cAMP‐dependent protein kinase was virtually the same in fibroblasts and various human tumour cell lines investigated.