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Medientyp:
E-Artikel
Titel:
Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesis
Beteiligte:
Pyrzynska, Beata;
Pilecka, Iwona;
Miaczynska, Marta
Erschienen:
Wiley, 2009
Erschienen in:
Molecular Oncology, 3 (2009) 4, Seite 321-338
Sprache:
Englisch
DOI:
10.1016/j.molonc.2009.06.001
ISSN:
1574-7891;
1878-0261
Entstehung:
Anmerkungen:
Beschreibung:
Accumulating evidence argues that many proteins governing membrane sorting during endocytosis participate also in nuclear signaling and transcriptional regulation, mostly by modulating the activity of various nuclear factors. Some adaptors and accessory proteins acting in clathrin‐mediated internalization, as well as endosomal sorting proteins can undergo nuclear translocation and affect gene expression directly, while for others the effects may be more indirect. Although it is often unclear to what extent the endocytic and nuclear functions are interrelated, several of such proteins are implicated in the regulation of cell proliferation and tumorigenesis, arguing that their dual‐function nature may be of physiological importance.