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Medientyp:
E-Artikel
Titel:
Established prognostic variables in NO oral carcinoma
Beteiligte:
Clark, Jonathan R.;
Naranjo, Natalie;
Franklin, Jason H.;
de Almeida, John;
Gullane, Patrick J.
Erschienen:
Wiley, 2006
Erschienen in:
Otolaryngology–Head and Neck Surgery, 135 (2006) 5, Seite 748-753
Sprache:
Englisch
DOI:
10.1016/j.otohns.2006.05.751
ISSN:
0194-5998;
1097-6817
Entstehung:
Anmerkungen:
Beschreibung:
OBJECTIVESTo examine the utility of established prognostic variables in patients with oral carcinoma and a clinically negative neck.STUDY DESIGNRetrospective cohort study.METHODSThe distribution of occult metastases was assessed in 105 oral cancer patients with no clinical or radiological evidence of nodal disease. Predictors for nodal metastases, recurrence, and survival were examined.RESULTSOccult neck metastases occurred in 34 percent of patients. Tumor thickness was the only independent predictor of occult metastases, with thin (‡5 mm) and thick (>5 mm) tumors having a 10 percent and 46 percent incidence of regional disease, respectively (P = 0.001). Nodal metastases and perineural invasion were significant predictors of survival.CONCLUSIONPatients with thick tumors are at high risk of nodal metastases and are likely to benefit from elective neck dissection. Comprehensive neck dissection should be considered in advanced primary disease.SIGNIFICANCETumor thickness is the most important predictor of occult regional metastases in oral cavity cancer.