> Detailanzeige
Peloso, Gina M.;
van der Lee, Sven J.;
Sims, R.;
van der Lee, S.J.;
Naj, A.C.;
Bellenguez, C.;
Badarinarayan, N.;
Jakobsdottir, J.;
Kunkle, B.W.;
Boland, A.;
Raybould, R.;
Bis, J.C.;
Martin, E.R.;
Grenier‐Boley, B.;
Heilmann‐Heimbach, S.;
Chouraki, V.;
Kuzma, A.B.;
Sleegers, K.;
Vronskaya, M.;
Ruiz, A.;
Graham, R.R.;
Olaso, R.;
Hoffmann, P.;
Grove, M.L.;
[...]
Genetically elevated high‐density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease
Teilen
Literatur-
verwaltung
Direktlink
Zur
Merkliste
Lösche von
Merkliste
Per Email teilen
Auf Twitter teilen
Auf Facebook teilen
Per Whatsapp teilen
- Medientyp: E-Artikel
- Titel: Genetically elevated high‐density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease
- Beteiligte: Peloso, Gina M.; van der Lee, Sven J.; Sims, R.; van der Lee, S.J.; Naj, A.C.; Bellenguez, C.; Badarinarayan, N.; Jakobsdottir, J.; Kunkle, B.W.; Boland, A.; Raybould, R.; Bis, J.C.; Martin, E.R.; Grenier‐Boley, B.; Heilmann‐Heimbach, S.; Chouraki, V.; Kuzma, A.B.; Sleegers, K.; Vronskaya, M.; Ruiz, A.; Graham, R.R.; Olaso, R.; Hoffmann, P.; Grove, M.L.; [...]
-
Erschienen:
Wiley, 2018
- Erschienen in: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 10 (2018) 1, Seite 595-598
- Sprache: Englisch
- DOI: 10.1016/j.dadm.2018.08.008
- ISSN: 2352-8729
- Schlagwörter: Psychiatry and Mental health ; Neurology (clinical)
- Entstehung:
- Anmerkungen:
- Beschreibung: AbstractIntroductionThere is conflicting evidence whether high‐density lipoprotein cholesterol (HDL‐C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (CETP) locus is associated with altered HDL‐C. We aimed to assess AD risk by genetically predicted HDL‐C.MethodsTen single nucleotide polymorphisms within the CETP locus predicting HDL‐C were applied to the International Genomics of Alzheimer's Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. We performed instrumental variables analysis using inverse variance weighting, weighted median, and MR‐Egger.ResultsBased on 10 single nucleotide polymorphisms distinctly predicting HDL‐C in the CETP locus, we found that HDL‐C was not associated with risk of AD (P > .7).DiscussionOur study does not support the role of HDL‐C on risk of AD through HDL‐C altered by CETP. This study does not rule out other mechanisms by which HDL‐C affects risk of AD.
- Zugangsstatus: Freier Zugang