Beschreibung:
<jats:p>The contributions of membrane type‐1 matrix metalloproteinase (MT1‐MMP) and of the glucose‐6‐phosphate transporter (G6PT) in sphingosine‐1‐phosphate (S1P)‐mediated Ca<jats:sup>2+</jats:sup> mobilization were assessed in glioblastoma cells. We show that gene silencing of MT1‐MMP or G6PT decreased the extent of S1P‐induced Ca<jats:sup>2+</jats:sup> mobilization, chemotaxis, and extracellular signal‐related kinase phosphorylation. Chlorogenic acid and (−)‐epigallocatechin‐3‐gallate, two diet‐derived inhibitors of G6PT and of MT1‐MMP, respectively, reduced S1P‐mediated Ca<jats:sup>2+</jats:sup> mobilization. An intact MT1‐MMP/G6PT signaling axis is thus required for efficient Ca<jats:sup>2+</jats:sup> mobilization in response to bioactive lipids such as S1P. Targeted inhibition of either MT1‐MMP or G6PT may lead to reduced infiltrative and invasive properties of brain tumor cells.</jats:p>