Beschreibung:
<jats:p>The impact of interleukin (IL)‐1ß on tumor necrosis factor α‐induced adipose‐related protein (TIARP)/six‐transmembrane protein of prostate 2 (STAMP2) was determined in adipocytes. TIARP/STAMP2 mRNA synthesis was significantly stimulated by IL‐1ß in a dose‐ and time‐dependent fashion in 3T3‐L1 adipocytes. Signaling studies suggested that janus kinase 2, nuclear factor κB, and p44/42 mitogen‐activated protein kinase are involved in IL‐1ß‐induced TIARP/STAMP2 mRNA expression. Furthermore, IL‐1ß, TNFα, and IL‐6 showed synergistic stimulatory effects on TIARP/STAMP2 gene expression. Moreover, both TIARP/STAMP2 mRNA synthesis and protein expression were induced by IL‐1ß in fully differentiated human mesenchymal stem cell‐derived adipocytes (hMSC‐Ad). Taken together, TIARP/STAMP2 is highly upregulated in 3T3‐L1 cells and hMSC‐Ad by IL‐1ß and might, therefore, modulate proinflammatory and insulin resistance‐inducing effects of IL‐1ß.</jats:p>