Erschienen in:International Journal of Gynecology & Obstetrics
Sprache:
Englisch
DOI:
10.1016/j.ijgo.2007.05.040
ISSN:
0020-7292;
1879-3479
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To determine whether further histologic assessment can be omitted after office sampling produced a nondiagnostic specimen.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Data were retrieved from a prospective cohort study of 913 women presenting with postmenopausal bleeding. This study was limited to women with an endometrial thickness either 5 mm or greater or that could not be measured, and in whom an endometrial biopsy performed in the office yielded nondiagnostic results.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Endometrial thickness was nonreassuring or unknown in 516 women, of whom 403 (78.1%) underwent office endometrial sampling. In 66 women the amount of tissue obtained was not sufficient for pathologic characterization. Further investigation revealed an endometrial malignancy in 3 of these 66 women and atypical hyperplasia in 1.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In women with postmenopausal bleeding and a nonreassuring transvaginal ultrasound evaluation, a nondiagnostic office endometrial sample does not rule out endometrial cancer and further endometrial sampling is advisable.</jats:p></jats:sec>