• Medientyp: E-Artikel
  • Titel: Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: A new approach
  • Beteiligte: Posner, Holly B.; Cano, Stefan; Carrillo, Maria C.; Selnes, Ola; Stern, Yaakov; Thomas, Ronald G.; Zajicek, John; Hobart, Jeremy
  • Erschienen: Wiley, 2013
  • Erschienen in: Alzheimer's & Dementia
  • Sprache: Englisch
  • DOI: 10.1016/j.jalz.2012.10.008
  • ISSN: 1552-5260; 1552-5279
  • Schlagwörter: Psychiatry and Mental health ; Cellular and Molecular Neuroscience ; Geriatrics and Gerontology ; Neurology (clinical) ; Developmental Neuroscience ; Health Policy ; Epidemiology
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  • Beschreibung: <jats:p>The Alzheimer's disease (AD) Cognitive Behavior Section (ADAS‐Cog) is the most commonly used cognitive test in clinical trials of AD. Recent trials have focused on people earlier in the course of disease; however, there are concerns about using the ADAS‐Cog at this crucial stage. Using data from the Alzheimer's disease Neuroimaging Initiative study, we used a range of traditional psychometric tests to evaluate those concerns. This issue of <jats:italic>Alzheimer's &amp; Dementia</jats:italic> includes two articles that evaluate the ADAS‐Cog. These articles report evaluations using two psychometric approaches: traditional methods and new methods. In this review, we provide accompanying background information to this program of research.</jats:p>