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Barnes, Josephine; Dickerson, Bradford C.; Frost, Chris; Jiskoot, Lize C.; Wolk, David; van der Flier, Wiesje M.

Alzheimer's disease first symptoms are age dependent: Evidence from the NACC dataset

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  • Medientyp: E-Artikel
  • Titel: Alzheimer's disease first symptoms are age dependent: Evidence from the NACC dataset
  • Beteiligte: Barnes, Josephine; Dickerson, Bradford C.; Frost, Chris; Jiskoot, Lize C.; Wolk, David; van der Flier, Wiesje M.
  • Erschienen: Wiley, 2015
  • Erschienen in: Alzheimer's & Dementia
  • Sprache: Englisch
  • DOI: 10.1016/j.jalz.2014.12.007
  • ISSN: 1552-5260; 1552-5279
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>Determining the relationship between age and Alzheimer's disease (AD) presentation is important to improve understanding and provide better patient services.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We used AD patient data (N = 7815) from the National Alzheimer Coordinating Center database and multinomial logistic regression to investigate presentation age and first cognitive/behavioral symptoms.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The odds of having a nonmemory first cognitive symptom (including impairment in judgment and problem solving, language, and visuospatial function) increased with younger age (<jats:italic>P</jats:italic> &lt;.001, all tests). Compared with apathy/withdrawal, the odds of having depression and “other” behavioral symptoms increased with younger age (<jats:italic>P</jats:italic> &lt;.02, both tests), whereas the odds of having psychosis and no behavioral symptom increased with older age (<jats:italic>P</jats:italic> &lt;.001, both tests).</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>There is considerable heterogeneity in the first cognitive/behavioral symptoms experienced by AD patients. Proportions of these symptoms change with age with patients experiencing increasing nonmemory cognitive symptoms and more behavioral symptoms at younger ages.</jats:p></jats:sec>