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Jun, Gyungah R.; Chung, Jaeyoon; Mez, Jesse; Barber, Robert; Beecham, Gary W.; Bennett, David A.; Buxbaum, Joseph D.; Byrd, Goldie S.; Carrasquillo, Minerva M.; Crane, Paul K.; Cruchaga, Carlos; De Jager, Philip; Ertekin‐Taner, Nilufer; Evans, Denis; Fallin, M. Danielle; Foroud, Tatiana M.; Friedland, Robert P.; Goate, Alison M.; Graff‐Radford, Neill R.; Hendrie, Hugh; Hall, Kathleen S.; Hamilton‐Nelson, Kara L.; Inzelberg, Rivka; Kamboh, M. Ilyas; [...]

Transethnic genome‐wide scan identifies novel Alzheimer's disease loci

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  • Medientyp: E-Artikel
  • Titel: Transethnic genome‐wide scan identifies novel Alzheimer's disease loci
  • Beteiligte: Jun, Gyungah R.; Chung, Jaeyoon; Mez, Jesse; Barber, Robert; Beecham, Gary W.; Bennett, David A.; Buxbaum, Joseph D.; Byrd, Goldie S.; Carrasquillo, Minerva M.; Crane, Paul K.; Cruchaga, Carlos; De Jager, Philip; Ertekin‐Taner, Nilufer; Evans, Denis; Fallin, M. Danielle; Foroud, Tatiana M.; Friedland, Robert P.; Goate, Alison M.; Graff‐Radford, Neill R.; Hendrie, Hugh; Hall, Kathleen S.; Hamilton‐Nelson, Kara L.; Inzelberg, Rivka; Kamboh, M. Ilyas; [...]
  • Erschienen: Wiley, 2017
  • Erschienen in: Alzheimer's & Dementia
  • Sprache: Englisch
  • DOI: 10.1016/j.jalz.2016.12.012
  • ISSN: 1552-5279; 1552-5260
  • Schlagwörter: Psychiatry and Mental health ; Cellular and Molecular Neuroscience ; Geriatrics and Gerontology ; Neurology (clinical) ; Developmental Neuroscience ; Health Policy ; Epidemiology
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We conducted a transethnic genome‐wide association study (GWAS) for late‐onset AD in Stage 1 sample including whites of European Ancestry, African‐Americans, Japanese, and Israeli‐Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Genome‐wide significant (GWS) associations in single‐nucleotide polymorphism (SNP)–based tests (<jats:italic>P</jats:italic> &lt; 5 × 10<jats:sup>−8</jats:sup>) were identified for SNPs in <jats:italic>PFDN1/HBEGF</jats:italic>, <jats:italic>USP6NL/ECHDC3</jats:italic>, and <jats:italic>BZRAP1‐AS1</jats:italic> and for the interaction of the (apolipoprotein E) <jats:italic>APOE</jats:italic> ε4 allele with <jats:italic>NFIC</jats:italic> SNP. We also obtained GWS evidence (<jats:italic>P</jats:italic> &lt; 2.7 × 10<jats:sup>−6</jats:sup>) for gene‐based association in the total sample with a novel locus, <jats:italic>TPBG</jats:italic> (<jats:italic>P</jats:italic> = 1.8 × 10<jats:sup>−6</jats:sup>).</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci.</jats:p></jats:sec>