Beschreibung:
<jats:p>The 825T allele of a common C825T polymorphism in the gene encoding the β3 subunit of heterotrimeric G proteins is associated with enhanced activation of pertussis toxin (PTX)‐sensitive G proteins. We investigated responses of human platelets upon stimulation with epinephrine, which activates PTX‐sensitive G proteins, and with agonists which activate additionally, or exclusively PTX‐insensitive pathways. Slopes and maximum of the secondary aggregation were significantly enhanced in platelets from 825T allele carriers after epinephrine, and after combined epinephrine/ADP. This effect was more pronounced after inhibition of the cyclooxygenase‐2 pathway by acetylsalicylic acid. This phenomenon appeared independent of platelet secretion, or inhibition of the adenylyl cyclase.</jats:p>