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Tessarolo, Louise Donadello; de Menezes, Ramon Róseo Paula Pessoa Bezerra; Mello, Clarissa Perdigão; Lima, Dânya Bandeira; Magalhães, Emanuel Paula; Bezerra, Eveline Matias; Sales, Francisco Adilson Matos; Barroso Neto, Ito Liberato; Oliveira, Maria de Fátima; dos Santos, Ricardo Pires; Albuquerque, Eudenilson L.; Freire, Valder Nogueira; Martins, Alice Maria

Nanoencapsulation of benznidazole in calcium carbonate increases its selectivity to Trypanosoma cruzi

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  • Medientyp: E-Artikel
  • Titel: Nanoencapsulation of benznidazole in calcium carbonate increases its selectivity to Trypanosoma cruzi
  • Beteiligte: Tessarolo, Louise Donadello; de Menezes, Ramon Róseo Paula Pessoa Bezerra; Mello, Clarissa Perdigão; Lima, Dânya Bandeira; Magalhães, Emanuel Paula; Bezerra, Eveline Matias; Sales, Francisco Adilson Matos; Barroso Neto, Ito Liberato; Oliveira, Maria de Fátima; dos Santos, Ricardo Pires; Albuquerque, Eudenilson L.; Freire, Valder Nogueira; Martins, Alice Maria
  • Erschienen: Cambridge University Press (CUP), 2018
  • Erschienen in: Parasitology, 145 (2018) 9, Seite 1191-1198
  • Sprache: Englisch
  • DOI: 10.1017/s0031182018000197
  • ISSN: 1469-8161; 0031-1820
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Chagas disease is a public health problem, affecting about 7 million people worldwide. Benznidazole (BZN) is the main treatment option, but it has limited effectiveness and can cause severe adverse effects. Drug delivery through nanoparticles has attracted the interest of the scientific community aiming to improve therapeutic options. The aim of this study was to evaluate the cytotoxicity of benznidazole-loaded calcium carbonate nanoparticles (BZN@CaCO<jats:sub>3</jats:sub>) on <jats:italic>Trypanosoma cruzi</jats:italic> strain Y. It was observed that BZN@CaCO<jats:sub>3</jats:sub> was able to reduce the viability of epimastigote, trypomastigote and amastigote forms of <jats:italic>T. cruzi</jats:italic> with greater potency when compared with BZN. The amount of BZN necessary to obtain the same effect was up to 25 times smaller when loaded with CaCO<jats:sub>3</jats:sub> nanoparticles. Also, it was observed that BZN@CaCO<jats:sub>3</jats:sub> enhanced the selectivity index. Furthermore, the cell-death mechanism induced by both BZN and BZN@CaCO<jats:sub>3</jats:sub> was evaluated, indicating that both substances caused necrosis and changed mitochondrial membrane potential.</jats:p>