White matter fiber microstructure is associated with prior hospitalizations rather than acute symptomatology in major depressive disorder

Medientyp: E-Artikel
Titel: White matter fiber microstructure is associated with prior hospitalizations rather than acute symptomatology in major depressive disorder
Beteiligte: Meinert, Susanne; Leehr, Elisabeth J.; Grotegerd, Dominik; Repple, Jonathan; Förster, Katharina; Winter, Nils R.; Enneking, Verena; Fingas, Stella M.; Lemke, Hannah; Waltemate, Lena; Stein, Frederike; Brosch, Katharina; Schmitt, Simon; Meller, Tina; Linge, Anna; Krug, Axel; Nenadić, Igor; Jansen, Andreas; Hahn, Tim; Redlich, Ronny; Opel, Nils; Schubotz, Ricarda I.; Baune, Bernhard T.; Kircher, Tilo;
Erschienen: Cambridge University Press (CUP), 2022
Erschienen in: Psychological Medicine
Sprache: Englisch
DOI: 10.1017/s0033291720002950
ISSN: 0033-2917; 1469-8978
Schlagwörter: Psychiatry and Mental health ; Applied Psychology
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Beschreibung: <jats:title>Abstract</jats:title><jats:sec id="S0033291720002950_sec_a1"><jats:title>Background</jats:title><jats:p>Eighty percent of all patients suffering from major depressive disorder (MDD) relapse at least once in their lifetime. Thus, understanding the neurobiological underpinnings of the course of MDD is of utmost importance. A detrimental course of illness in MDD was most consistently associated with superior longitudinal fasciculus (SLF) fiber integrity. As similar associations were, however, found between SLF fiber integrity and acute symptomatology, this study attempts to disentangle associations attributed to current depression from long-term course of illness.</jats:p></jats:sec><jats:sec id="S0033291720002950_sec_a2" sec-type="methods"><jats:title>Methods</jats:title><jats:p>A total of 531 patients suffering from acute (<jats:italic>N</jats:italic> = 250) or remitted (<jats:italic>N</jats:italic> = 281) MDD from the FOR2107-cohort were analyzed in this cross-sectional study using tract-based spatial statistics for diffusion tensor imaging. First, the effects of disease state (acute <jats:italic>v</jats:italic>. remitted), current symptom severity (BDI-score) and course of illness (number of hospitalizations) on fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity were analyzed separately. Second, disease state and BDI-scores were analyzed in conjunction with the number of hospitalizations to disentangle their effects.</jats:p></jats:sec><jats:sec id="S0033291720002950_sec_a3" sec-type="results"><jats:title>Results</jats:title><jats:p>Disease state (<jats:italic>p</jats:italic><jats:sub>FWE</jats:sub> < 0.042) and number of hospitalizations (<jats:italic>p</jats:italic><jats:sub>FWE</jats:sub><jats:italic><</jats:italic> 0.032) were associated with decreased FA and increased MD and RD in the bilateral SLF. A trend was found for the BDI-score (<jats:italic>p</jats:italic><jats:sub>FWE</jats:sub> > 0.067). When analyzed simultaneously only the effect of course of illness remained significant (<jats:italic>p</jats:italic><jats:sub>FWE</jats:sub> < 0.040) mapping to the right SLF.</jats:p></jats:sec><jats:sec id="S0033291720002950_sec_a4" sec-type="conclusions"><jats:title>Conclusions</jats:title><jats:p>Decreased FA and increased MD and RD values in the SLF are associated with more hospitalizations when controlling for current psychopathology. SLF fiber integrity could reflect cumulative illness burden at a neurobiological level and should be targeted in future longitudinal analyses.</jats:p></jats:sec>

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