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Buisman, Leander R.; Rutten-van Mölken, Maureen P.M.H.; Postmus, Douwe; Luime, Jolanda J.; Uyl-de Groot, Carin A.; Redekop, William K.

THE EARLY BIRD CATCHES THE WORM: EARLY COST-EFFECTIVENESS ANALYSIS OF NEW MEDICAL TESTS

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  • Medientyp: E-Artikel
  • Titel: THE EARLY BIRD CATCHES THE WORM: EARLY COST-EFFECTIVENESS ANALYSIS OF NEW MEDICAL TESTS
  • Beteiligte: Buisman, Leander R.; Rutten-van Mölken, Maureen P.M.H.; Postmus, Douwe; Luime, Jolanda J.; Uyl-de Groot, Carin A.; Redekop, William K.
  • Erschienen: Cambridge University Press (CUP), 2016
  • Erschienen in: International Journal of Technology Assessment in Health Care, 32 (2016) 1-2, Seite 46-53
  • Sprache: Englisch
  • DOI: 10.1017/s0266462316000064
  • ISSN: 0266-4623; 1471-6348
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Objectives:There is little specific guidance on performing an early cost-effectiveness analysis (CEA) of medical tests. We developed a framework with general steps and applied it to two cases.Methods:Step 1 is to narrow down the scope of analysis by defining the test's application, target population, outcome measures, and investigating current test strategies and test strategies if the new test were available. Step 2 is to collect evidence on the current test strategy. Step 3 is to develop a conceptual model of the current and new test strategies. Step 4 is to conduct the early-CEA by evaluating the potential (cost-)effectiveness of the new test in clinical practice. Step 5 involves a decision about the further development of the test.Results:The first case illustrated the impact of varying the test performance on the headroom (maximum possible price) of an add-on test for patients with an intermediate-risk of having rheumatoid arthritis. Analyses showed that the headroom is particularly dependent on test performance. The second case estimated the minimum performance of a confirmatory imaging test to predict individual stroke risk. Different combinations of sensitivity and specificity were found to be cost-effective; if these combinations are attainable, the medical test developer can feel more confident about the value of further development of the test.Conclusions:A well-designed early-CEA methodology can improve the ability to develop (cost-)effective medical tests in an efficient manner. Early-CEAs should continuously integrate insights and evidence that arise through feedback, which may convince developers to return to earlier steps.