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Alqahtani, F.Y.; Aleanizy, F.S.; Ali El Hadi Mohamed, R.; Alanazi, M. S.; Mohamed, N.; Alrasheed, M. M.; Abanmy, N.; Alhawassi, T.

Prevalence of comorbidities in cases of Middle East respiratory syndrome coronavirus: a retrospective study

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  • Medientyp: E-Artikel
  • Titel: Prevalence of comorbidities in cases of Middle East respiratory syndrome coronavirus: a retrospective study
  • Beteiligte: Alqahtani, F.Y.; Aleanizy, F.S.; Ali El Hadi Mohamed, R.; Alanazi, M. S.; Mohamed, N.; Alrasheed, M. M.; Abanmy, N.; Alhawassi, T.
  • Erschienen: Cambridge University Press (CUP), 2019
  • Erschienen in: Epidemiology and Infection
  • Sprache: Englisch
  • DOI: 10.1017/s0950268818002923
  • ISSN: 1469-4409; 0950-2688
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>The Middle East respiratory syndrome coronavirus (MERS-CoV) is a life-threatening respiratory disease with a high case fatality rate; however, its risk factors remain unclear. We aimed to explore the influence of demographic factors, clinical manifestations and underlying comorbidities on mortality in MERS-CoV patients. Retrospective chart reviews were performed to identify all laboratory-confirmed cases of MERS-COV infection in Saudi Arabia that were reported to the Ministry of Health of Saudi Arabia between 23 April 2014 and 7 June 2016. Statistical analyses were conducted to assess the effect of sex, age, clinical presentation and comorbidities on mortality from MERS-CoV. A total of 281 confirmed MERS-CoV cases were identified: 167 (59.4%) patients were male and 55 (20%) died. Mortality predominantly occurred among Saudi nationals and older patients and was significantly associated with respiratory failure and shortness of breath. Of the 281 confirmed cases, 160 (56.9%) involved comorbidities, wherein diabetes mellitus, hypertension, ischemic heart disease, congestive heart failure, end-stage renal disease and chronic kidney disease were significantly associated with mortality from MERS-CoV and two or three comorbidities significantly affected the fatality rates from MERS-CoV. The findings of this study show that old age and the existence of underlying comorbidities significantly increase mortality from MERS-CoV.</jats:p>
  • Zugangsstatus: Freier Zugang