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Satake, Yuto; Kanemoto, Hideki; Taomoto, Daiki; Suehiro, Takashi; Koizumi, Fuyuki; Sato, Shunsuke; Wada, Tamiki; Matsunaga, Keiko; Shimosegawa, Eku; Gotoh, Shiho; Mori, Kohji; Morihara, Takashi; Yoshiyama, Kenji; Ikeda, Manabu

Characteristics of very late-onset schizophrenia-like psychosis classified with the biomarkers for Alzheimer’s disease: a retrospective cross-sectional study

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  • Medientyp: E-Artikel
  • Titel: Characteristics of very late-onset schizophrenia-like psychosis classified with the biomarkers for Alzheimer’s disease: a retrospective cross-sectional study
  • Beteiligte: Satake, Yuto; Kanemoto, Hideki; Taomoto, Daiki; Suehiro, Takashi; Koizumi, Fuyuki; Sato, Shunsuke; Wada, Tamiki; Matsunaga, Keiko; Shimosegawa, Eku; Gotoh, Shiho; Mori, Kohji; Morihara, Takashi; Yoshiyama, Kenji; Ikeda, Manabu
  • Erschienen: Cambridge University Press (CUP), 2024
  • Erschienen in: International Psychogeriatrics
  • Sprache: Englisch
  • DOI: 10.1017/s1041610222001132
  • ISSN: 1741-203X; 1041-6102
  • Schlagwörter: Psychiatry and Mental health ; Geriatrics and Gerontology ; Gerontology ; Clinical Psychology
  • Entstehung:
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  • Beschreibung: <jats:title>ABSTRACT</jats:title><jats:sec id="S1041610222001132_as1"><jats:title>Objectives:</jats:title><jats:p>We aimed to investigate the association between very late-onset schizophrenia-like psychosis (VLOSLP), a schizophrenia spectrum disorder with an onset of ≥60 years, and Alzheimer’s disease (AD) using biomarkers.</jats:p></jats:sec><jats:sec id="S1041610222001132_as2"><jats:title>Design:</jats:title><jats:p>Retrospective cross-sectional study.</jats:p></jats:sec><jats:sec id="S1041610222001132_as3"><jats:title>Setting:</jats:title><jats:p>Neuropsychology clinic of Osaka University Hospital in Japan.</jats:p></jats:sec><jats:sec id="S1041610222001132_as4"><jats:title>Participants:</jats:title><jats:p>Thirty-three participants were classified into three groups: eight AD biomarker-negative VLOSLP (VLOSLP−AD), nine AD biomarker-positive VLOSLP (VLOSLP+AD), and sixteen amnestic mild cognitive impairment due to AD without psychosis (aMCI−P+AD) participants.</jats:p></jats:sec><jats:sec id="S1041610222001132_as5"><jats:title>Measurements:</jats:title><jats:p>Phosphorylated tau levels in the cerebrospinal fluid and <jats:sup>18</jats:sup>F-Florbetapir positron emission tomography results were used as AD biomarkers. Several scales (e.g. the Mini-Mental State Examination (MMSE), Wechsler Memory Scale-Revised (WMS-R) Logical Memory (LM) I and II, and Neuropsychiatric Inventory (NPI)-plus) were conducted to assess clinical characteristics.</jats:p></jats:sec><jats:sec id="S1041610222001132_as6"><jats:title>Results:</jats:title><jats:p>Those in both VLOSLP−AD and +AD groups scored higher than those in aMCI−P+AD in WMS-R LM I. On the other hand, VLOSLP+AD participants scored in between the other two groups in the WMS-R LM II, with only VLOSLP−AD participants scoring significantly higher than aMCI−P+AD participants. There were no significant differences in sex distribution and MMSE scores among the three groups or in the subtype of psychotic symptoms between VLOSLP−AD and +AD participants. Four VLOSLP−AD and five VLOSLP+AD participants harbored partition delusions. Delusion of theft was shown in two VLOSLP−AD patients and five VLOSLP+AD patients.</jats:p></jats:sec><jats:sec id="S1041610222001132_as7"><jats:title>Conclusion:</jats:title><jats:p>Some VLOSLP patients had AD pathology. Clinical characteristics were different between AD biomarker-positive and AD biomarker-negative VLOSLP, which may be helpful for detecting AD pathology in VLOSLP patients.</jats:p></jats:sec>