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Seol, Ju Eun; Kim, Jeongseon; Lee, Bong-Hwa; Hwang, Dae-Yong; Jeong, Jinyoung; Lee, Hun-Jae; Ahn, Yoon-Ok; Lee, Jung Eun; Kim, Dong-Hyun

Folate, alcohol, ADH1B and ALDH2 and colorectal cancer risk

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  • Medientyp: E-Artikel
  • Titel: Folate, alcohol, ADH1B and ALDH2 and colorectal cancer risk
  • Beteiligte: Seol, Ju Eun; Kim, Jeongseon; Lee, Bong-Hwa; Hwang, Dae-Yong; Jeong, Jinyoung; Lee, Hun-Jae; Ahn, Yoon-Ok; Lee, Jung Eun; Kim, Dong-Hyun
  • Erschienen: Cambridge University Press (CUP), 2021
  • Erschienen in: Public Health Nutrition
  • Sprache: Englisch
  • DOI: 10.1017/s136898001900452x
  • ISSN: 1368-9800; 1475-2727
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec id="S136898001900452X_as1"><jats:title>Objective:</jats:title><jats:p>There is limited evidence on the interaction by <jats:italic>alcohol dehydrogenase</jats:italic> 2 (<jats:italic>ADH1B</jats:italic>) (rs1229984) and <jats:italic>aldehyde dehydrogenase</jats:italic> 2 (<jats:italic>ALDH2</jats:italic>) (rs671) regarding the associations of alcohol and a methyl diet (low folate and high alcohol intake) with cancer risk, partly because of rare polymorphisms in Western populations.</jats:p></jats:sec><jats:sec id="S136898001900452X_as2"><jats:title>Design:</jats:title><jats:p>In a case–control study, we estimated the ORs and 95 % CIs to evaluate the associations of <jats:italic>ADH1B</jats:italic> and <jats:italic>ALDH2</jats:italic> genotypes with colorectal cancer (CRC) and the joint association between methyl diets and <jats:italic>ADH1B</jats:italic> and <jats:italic>ALDH2</jats:italic> polymorphisms with CRC risk using logistic regression models.</jats:p></jats:sec><jats:sec id="S136898001900452X_as3"><jats:title>Setting:</jats:title><jats:p>A hospital-based case–control study.</jats:p></jats:sec><jats:sec id="S136898001900452X_as4"><jats:title>Participants:</jats:title><jats:p>In total, 1001 CRC cases and 899 cancer-free controls admitted to two university hospitals.</jats:p></jats:sec><jats:sec id="S136898001900452X_as5"><jats:title>Results:</jats:title><jats:p>We found that alcohol intake increased the risk of CRC; OR (95 % CI) was 2·02 (1·41, 2·87) for ≥60 g/d drinkers compared with non-drinkers (<jats:italic>P</jats:italic><jats:sub>trend</jats:sub> &lt; 0·001). The associations for two polymorphisms with CRC were not statistically significant. However, we found a potential interaction of <jats:italic>ALDH2</jats:italic> with methyl diets and CRC. We observed a 9·08-fold (95 % CI 1·93, 42·60) higher risk of CRC for low-methyl diets compared with high-methyl diets among individuals with an <jats:italic>A</jats:italic> allele of <jats:italic>ALDH2</jats:italic>, but the association was not apparent among those with <jats:italic>ALDH2 GG</jats:italic> (<jats:italic>P</jats:italic><jats:sub>interaction</jats:sub> = 0·02).</jats:p></jats:sec><jats:sec id="S136898001900452X_as6"><jats:title>Conclusions:</jats:title><jats:p>Our data support the evidence that gene–methyl diet interactions may be involved in CRC risk in East Asian populations, showing that a low-methyl diet increased the risk of CRC among individuals with an <jats:italic>A</jats:italic> allele of <jats:italic>ALDH2</jats:italic>.</jats:p></jats:sec>
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