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Shukla, Manojkumar R.; Patra, Sukanya; Verma, Mahip; Sadasivam, Gayathri; Jana, Nirmal; Mahangare, Sachin J.; Vidhate, Prashant; Lagad, Dipak; Tarage, Anand; Cheemala, Murthy; Kulkarni, Chaitanya; Bhagwat, Shankar; Chaudhari, Vinod D.; Sayyed, Majid; Pachpute, Vipul; Phadtare, Ramesh; Gole, Gopal; Phukan, Samiron; Sunkara, Brahmam; Samant, Charudatt; Shingare, Manisha; Naik, Aditya; Trivedi, Sneha; Marisetti, Ajit Kumar; [...]

Discovery of a Potent and Selective PI3Kδ Inhibitor (S)-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4H-quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models

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  • Medientyp: E-Artikel
  • Titel: Discovery of a Potent and Selective PI3Kδ Inhibitor (S)-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4H-quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models
  • Beteiligte: Shukla, Manojkumar R.; Patra, Sukanya; Verma, Mahip; Sadasivam, Gayathri; Jana, Nirmal; Mahangare, Sachin J.; Vidhate, Prashant; Lagad, Dipak; Tarage, Anand; Cheemala, Murthy; Kulkarni, Chaitanya; Bhagwat, Shankar; Chaudhari, Vinod D.; Sayyed, Majid; Pachpute, Vipul; Phadtare, Ramesh; Gole, Gopal; Phukan, Samiron; Sunkara, Brahmam; Samant, Charudatt; Shingare, Manisha; Naik, Aditya; Trivedi, Sneha; Marisetti, Ajit Kumar; [...]
  • Erschienen: American Chemical Society (ACS), 2020
  • Erschienen in: Journal of Medicinal Chemistry, 63 (2020) 23, Seite 14700-14723
  • Sprache: Englisch
  • DOI: 10.1021/acs.jmedchem.0c01264
  • ISSN: 0022-2623; 1520-4804
  • Schlagwörter: Drug Discovery ; Molecular Medicine
  • Entstehung:
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