Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN)

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Titel: Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN)
Beteiligte: Heck, Michael C.; Wagner, Carl E.; Shahani, Pritika H.; MacNeill, Mairi; Grozic, Aleksandra; Darwaiz, Tamana; Shimabuku, Micah; Deans, David G.; Robinson, Nathan M.; Salama, Samer H.; Ziller, Joseph W.; Ma, Ning; van der Vaart, Arjan; Marshall, Pamela A.; Jurutka, Peter W.
Erschienen: American Chemical Society (ACS), 2016
Erschienen in: Journal of Medicinal Chemistry, 59 (2016) 19, Seite 8924-8940
Sprache: Englisch
DOI: 10.1021/acs.jmedchem.6b00812
ISSN: 0022-2623; 1520-4804
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