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Busch, Hans-Joerg; Schirmer, Stephan H; Jost, Marco; van Stijn, Sylvia; Peters, Stephan L M; Piek, Jan J; Bode, Christoph; Buschmann, Ivo R; Mies, Guenter

Leptin Augments Cerebral Hemodynamic Reserve after Three-Vessel Occlusion: Distinct Effects on Cerebrovascular Tone and Proliferation in a Nonlethal Model of Hypoperfused Rat Brain

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  • Medientyp: E-Artikel
  • Titel: Leptin Augments Cerebral Hemodynamic Reserve after Three-Vessel Occlusion: Distinct Effects on Cerebrovascular Tone and Proliferation in a Nonlethal Model of Hypoperfused Rat Brain
  • Beteiligte: Busch, Hans-Joerg; Schirmer, Stephan H; Jost, Marco; van Stijn, Sylvia; Peters, Stephan L M; Piek, Jan J; Bode, Christoph; Buschmann, Ivo R; Mies, Guenter
  • Erschienen: SAGE Publications, 2011
  • Erschienen in: Journal of Cerebral Blood Flow & Metabolism
  • Sprache: Englisch
  • DOI: 10.1038/jcbfm.2010.192
  • ISSN: 0271-678X; 1559-7016
  • Schlagwörter: Cardiology and Cardiovascular Medicine ; Neurology (clinical) ; Neurology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p> The adipocytokine leptin has distinct functions regulating vascular tone, inflammation, and collateral artery growth. Arteriogenesis is an inflammatory process and provides a mechanism to overcome the effects of vascular obstruction. We, therefore, tested the effects of leptin in hypoperfused rat brain (three-vessel occlusion). Systemic leptin administration for 1 week after occlusion surgery increased cerebral hemodynamic reserve similar to granulocyte–macrophage colony-stimulating factor (GM-CSF), as indicated by improved CO<jats:sub>2</jats:sub> reactivity (vehicle 0.53%±0.26% versus leptin 1.05%±0.6% per mm Hg arterial pCO<jats:sub>2</jats:sub>, P&lt;0.05). Infusion of microspheres under maximal vasodilation failed to show a positive effect of leptin on cerebral perfusion (vehicle 64.9%±4.5% versus leptin 66.3%±7.0%, occluded/nonoccluded hemisphere). Acute treatment with GM-CSF led to a significant increased CO<jats:sub>2</jats:sub> reactivity and cerebral perfusion (79.2%±8.1% versus 64.9%±4.5%, P&lt;0.05). Vasoconstrictive response of isolated rat carotid artery rings, after phenylephrine was attenuated at 24 hours following preincubation with leptin, was unaffected by removal of endothelium but abrogated by coculture with N-(omega)-nitro-l-arginine methylester, pointing toward an inducible nitric oxide synthase-mediated mechanism. In chronic cerebral hypoperfusion, acute leptin treatment restored the hemodynamic reserve of the cerebral vasculature through its effects on vascular tone, while leaving vascular outward remodeling unaffected. Our results, for the first time, reveal a protective role of leptin on vascular function in hemodynamically compromised brain tissue. </jats:p>
  • Zugangsstatus: Freier Zugang