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Cordell, Heather J.;
Han, Younghun;
Mells, George F.;
Li, Yafang;
Hirschfield, Gideon M.;
Greene, Casey S.;
Xie, Gang;
Juran, Brian D.;
Zhu, Dakai;
Qian, David C.;
Floyd, James A. B.;
Morley, Katherine I.;
Prati, Daniele;
Lleo, Ana;
Cusi, Daniele;
Schlicht, Erik M;
Lammert, Craig;
Atkinson, Elizabeth J;
Chan, Landon L;
de Andrade, Mariza;
Balschun, Tobias;
Mason, Andrew L;
Myers, Robert P;
Zhang, Jinyi;
[...]
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
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- Medientyp: E-Artikel
- Titel: International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
- Beteiligte: Cordell, Heather J.; Han, Younghun; Mells, George F.; Li, Yafang; Hirschfield, Gideon M.; Greene, Casey S.; Xie, Gang; Juran, Brian D.; Zhu, Dakai; Qian, David C.; Floyd, James A. B.; Morley, Katherine I.; Prati, Daniele; Lleo, Ana; Cusi, Daniele; Schlicht, Erik M; Lammert, Craig; Atkinson, Elizabeth J; Chan, Landon L; de Andrade, Mariza; Balschun, Tobias; Mason, Andrew L; Myers, Robert P; Zhang, Jinyi; [...]
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Erschienen:
Springer Science and Business Media LLC, 2015
- Erschienen in: Nature Communications, 6 (2015) 1
- Sprache: Englisch
- DOI: 10.1038/ncomms9019
- ISSN: 2041-1723
- Entstehung:
- Anmerkungen:
- Beschreibung: AbstractPrimary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10−8) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine–cytokine pathways, for which relevant therapies exist.
- Zugangsstatus: Freier Zugang