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Kamoun, Aurélie; Idbaih, Ahmed; Dehais, Caroline; Elarouci, Nabila; Carpentier, Catherine; Letouzé, Eric; Colin, Carole; Mokhtari, Karima; Jouvet, Anne; Uro-Coste, Emmanuelle; Martin-Duverneuil, Nadine; Sanson, Marc; Delattre, Jean-Yves; Figarella-Branger, Dominique; de Reyniès, Aurélien; Ducray, François; Adam, Clovis; Andraud, Marie; Aubriot-Lorton, Marie-Hélène; Bauchet, Luc; Beauchesne, Patrick; Bielle, Franck; Blechet, Claire; Campone, Mario; [...]

Integrated multi-omics analysis of oligodendroglial tumours identifies three subgroups of 1p/19q co-deleted gliomas

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  • Medientyp: E-Artikel
  • Titel: Integrated multi-omics analysis of oligodendroglial tumours identifies three subgroups of 1p/19q co-deleted gliomas
  • Beteiligte: Kamoun, Aurélie; Idbaih, Ahmed; Dehais, Caroline; Elarouci, Nabila; Carpentier, Catherine; Letouzé, Eric; Colin, Carole; Mokhtari, Karima; Jouvet, Anne; Uro-Coste, Emmanuelle; Martin-Duverneuil, Nadine; Sanson, Marc; Delattre, Jean-Yves; Figarella-Branger, Dominique; de Reyniès, Aurélien; Ducray, François; Adam, Clovis; Andraud, Marie; Aubriot-Lorton, Marie-Hélène; Bauchet, Luc; Beauchesne, Patrick; Bielle, Franck; Blechet, Claire; Campone, Mario; [...]
  • Erschienen: Springer Science and Business Media LLC, 2016
  • Erschienen in: Nature Communications
  • Sprache: Englisch
  • DOI: 10.1038/ncomms11263
  • ISSN: 2041-1723
  • Schlagwörter: General Physics and Astronomy ; General Biochemistry, Genetics and Molecular Biology ; General Chemistry ; Multidisciplinary
  • Entstehung:
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Oligodendroglial tumours (OT) are a heterogeneous group of gliomas. Three molecular subgroups are currently distinguished on the basis of the <jats:italic>IDH</jats:italic> mutation and 1p/19q co-deletion. Here we present an integrated analysis of the transcriptome, genome and methylome of 156 OT. Not only does our multi-omics classification match the current classification but also reveals three subgroups within 1p/19q co-deleted tumours, associated with specific expression patterns of nervous system cell types: oligodendrocyte, oligodendrocyte precursor cell (OPC) and neuronal lineage. We confirm the validity of these three subgroups using public datasets. Importantly, the OPC-like group is associated with more aggressive clinical and molecular patterns, including <jats:italic>MYC</jats:italic> activation. We show that the <jats:italic>MYC</jats:italic> activation occurs through various alterations, including <jats:italic>MYC</jats:italic> genomic gain, <jats:italic>MAX</jats:italic> genomic loss, <jats:italic>MYC</jats:italic> hypomethylation and microRNA-34b/c down-regulation. In the lower grade glioma TCGA dataset, the OPC-like group is associated with a poorer outcome independently of histological grade. Our study reveals previously unrecognized heterogeneity among 1p/19q co-deleted tumours.</jats:p>
  • Zugangsstatus: Freier Zugang