Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Motor neurons control blood vessel patterning in the developing spinal cord
Beteiligte:
Himmels, Patricia;
Paredes, Isidora;
Adler, Heike;
Karakatsani, Andromachi;
Luck, Robert;
Marti, Hugo H.;
Ermakova, Olga;
Rempel, Eugen;
Stoeckli, Esther T.;
Ruiz de Almodóvar, Carmen
Erschienen:
Springer Science and Business Media LLC, 2017
Erschienen in:Nature Communications
Sprache:
Englisch
DOI:
10.1038/ncomms14583
ISSN:
2041-1723
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title><jats:p>Formation of a precise vascular network within the central nervous system is of critical importance to assure delivery of oxygen and nutrients and for accurate functionality of neuronal networks. Vascularization of the spinal cord is a highly stereotypical process. However, the guidance cues controlling blood vessel patterning in this organ remain largely unknown. Here we describe a new neuro-vascular communication mechanism that controls vessel guidance in the developing spinal cord. We show that motor neuron columns remain avascular during a developmental time window, despite expressing high levels of the pro-angiogenic vascular endothelial growth factor (VEGF). We describe that motor neurons express the VEGF trapping receptor sFlt1 via a Neuropilin-1-dependent mechanism. Using a VEGF gain-of-function approach in mice and a motor neuron-specific sFlt1 loss-of-function approach in chicken, we show that motor neurons control blood vessel patterning by an autocrine mechanism that titrates motor neuron-derived VEGF via their own expression of sFlt1.</jats:p>