• Medientyp: E-Artikel
  • Titel: miR-184 represses β-catenin and behaves as a skin tumor suppressor
  • Beteiligte: Turovsky, Lubov; Kheshaiboun, Ghazal; Yassen, Gharam; Nagosa, Sara; Boyango, Ilanit; Amitai-Lange, Aya; Bhattacharya, Swarnabh; Ilan, Neta; Vlodavsky, Israel; Aberdam, Daniel; Shalom-Feuerstein, Ruby; Avitan-Hersh, Emily
  • Erschienen: Springer Science and Business Media LLC, 2024
  • Erschienen in: Cell Death & Disease, 15 (2024) 2
  • Sprache: Englisch
  • DOI: 10.1038/s41419-024-06554-4
  • ISSN: 2041-4889
  • Schlagwörter: Cancer Research ; Cell Biology ; Cellular and Molecular Neuroscience ; Immunology
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  • Beschreibung: AbstractmiR-184-knockout mice display perturbed epidermal stem cell differentiation. However, the potential role of miR-184 in skin pathology is unclear. Here, we report that miR-184 controls epidermal stem cell dynamics and that miR-184 ablation enhances skin carcinogenesis in mice. In agreement, repression of miR-184 in human squamous cell carcinoma (SCC) enhances neoplastic hallmarks of human SCC cells in vitro and tumor development in vivo. Characterization of miR-184-regulatory network, suggests that miR-184 inhibits pro-oncogenic pathways, cell proliferation, and epithelial to mesenchymal transformation. Of note, depletion of miR-184 enhances the levels of β-catenin under homeostasis and following experimental skin carcinogenesis. Finally, the repression of β-catenin by miR-184, inhibits the neoplastic phenotype of SCC cells. Taken together, miR-184 behaves as an epidermal tumor suppressor, and may provide a potentially useful target for skin SCC therapy.
  • Zugangsstatus: Freier Zugang