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Saffouri, George B.; Shields-Cutler, Robin R.; Chen, Jun; Yang, Yi; Lekatz, Heather R.; Hale, Vanessa L.; Cho, Janice M.; Battaglioli, Eric J.; Bhattarai, Yogesh; Thompson, Kevin J.; Kalari, Krishna K.; Behera, Gaurav; Berry, Jonathan C.; Peters, Stephanie A.; Patel, Robin; Schuetz, Audrey N.; Faith, Jeremiah J.; Camilleri, Michael; Sonnenburg, Justin L.; Farrugia, Gianrico; Swann, Jonathan R.; Grover, Madhusudan; Knights, Dan; Kashyap, Purna C.

Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders

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  • Medientyp: E-Artikel
  • Titel: Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders
  • Beteiligte: Saffouri, George B.; Shields-Cutler, Robin R.; Chen, Jun; Yang, Yi; Lekatz, Heather R.; Hale, Vanessa L.; Cho, Janice M.; Battaglioli, Eric J.; Bhattarai, Yogesh; Thompson, Kevin J.; Kalari, Krishna K.; Behera, Gaurav; Berry, Jonathan C.; Peters, Stephanie A.; Patel, Robin; Schuetz, Audrey N.; Faith, Jeremiah J.; Camilleri, Michael; Sonnenburg, Justin L.; Farrugia, Gianrico; Swann, Jonathan R.; Grover, Madhusudan; Knights, Dan; Kashyap, Purna C.
  • Erschienen: Springer Science and Business Media LLC, 2019
  • Erschienen in: Nature Communications
  • Sprache: Englisch
  • DOI: 10.1038/s41467-019-09964-7
  • ISSN: 2041-1723
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly defined and treatment involves non-specific antibiotics. Here we show that SIBO based on duodenal aspirate culture reflects an overgrowth of anaerobes, does not correspond with patient symptoms, and may be a result of dietary preferences. Small intestinal microbial composition, on the other hand, is significantly altered in symptomatic patients and does not correspond with aspirate culture results. In a pilot interventional study we found that switching from a high fiber diet to a low fiber, high simple sugar diet triggered FGID-related symptoms and decreased small intestinal microbial diversity while increasing small intestinal permeability. Our findings demonstrate that characterizing small intestinal microbiomes in patients with gastrointestinal symptoms may allow a more targeted antibacterial or a diet-based approach to treatment.</jats:p>
  • Zugangsstatus: Freier Zugang