Orchestrated ensemble activities constitute a hippocampal memory engram

Medientyp: E-Artikel

Titel: Orchestrated ensemble activities constitute a hippocampal memory engram

Beteiligte: Ghandour, Khaled; Ohkawa, Noriaki; Fung, Chi Chung Alan; Asai, Hirotaka; Saitoh, Yoshito; Takekawa, Takashi; Okubo-Suzuki, Reiko; Soya, Shingo; Nishizono, Hirofumi; Matsuo, Mina; Osanai, Makoto; Sato, Masaaki; Ohkura, Masamichi; Nakai, Junichi; Hayashi, Yasunori; Sakurai, Takeshi; Kitamura, Takashi; Fukai, Tomoki; Inokuchi, Kaoru

Erschienen: Springer Science and Business Media LLC, 2019

Sprache: Englisch

DOI: 10.1038/s41467-019-10683-2

ISSN: 2041-1723

Schlagwörter: General Physics and Astronomy ; General Biochemistry, Genetics and Molecular Biology ; General Chemistry ; Multidisciplinary

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Beschreibung: AbstractThe brain stores and recalls memories through a set of neurons, termed engram cells. However, it is unclear how these cells are organized to constitute a corresponding memory trace. We established a unique imaging system that combines Ca2+ imaging and engram identification to extract the characteristics of engram activity by visualizing and discriminating between engram and non-engram cells. Here, we show that engram cells detected in the hippocampus display higher repetitive activity than non-engram cells during novel context learning. The total activity pattern of the engram cells during learning is stable across post-learning memory processing. Within a single engram population, we detected several sub-ensembles composed of neurons collectively activated during learning. Some sub-ensembles preferentially reappear during post-learning sleep, and these replayed sub-ensembles are more likely to be reactivated during retrieval. These results indicate that sub-ensembles represent distinct pieces of information, which are then orchestrated to constitute an entire memory.

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