> Detailanzeige

Coutzac, Clélia; Jouniaux, Jean-Mehdi; Paci, Angelo; Schmidt, Julien; Mallardo, Domenico; Seck, Atmane; Asvatourian, Vahe; Cassard, Lydie; Saulnier, Patrick; Lacroix, Ludovic; Woerther, Paul-Louis; Vozy, Aurore; Naigeon, Marie; Nebot-Bral, Laetitia; Desbois, Mélanie; Simeone, Ester; Mateus, Christine; Boselli, Lisa; Grivel, Jonathan; Soularue, Emilie; Lepage, Patricia; Carbonnel, Franck; Ascierto, Paolo Antonio; Robert, Caroline;

Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer
  • Beteiligte: Coutzac, Clélia; Jouniaux, Jean-Mehdi; Paci, Angelo; Schmidt, Julien; Mallardo, Domenico; Seck, Atmane; Asvatourian, Vahe; Cassard, Lydie; Saulnier, Patrick; Lacroix, Ludovic; Woerther, Paul-Louis; Vozy, Aurore; Naigeon, Marie; Nebot-Bral, Laetitia; Desbois, Mélanie; Simeone, Ester; Mateus, Christine; Boselli, Lisa; Grivel, Jonathan; Soularue, Emilie; Lepage, Patricia; Carbonnel, Franck; Ascierto, Paolo Antonio; Robert, Caroline;
  • Erschienen: Springer Science and Business Media LLC, 2020
  • Erschienen in: Nature Communications
  • Sprache: Englisch
  • DOI: 10.1038/s41467-020-16079-x
  • ISSN: 2041-1723
  • Schlagwörter: General Physics and Astronomy ; General Biochemistry, Genetics and Molecular Biology ; General Chemistry ; Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Gut microbiota composition influences the clinical benefit of immune checkpoints in patients with advanced cancer but mechanisms underlying this relationship remain unclear. Molecular mechanism whereby gut microbiota influences immune responses is mainly assigned to gut microbial metabolites. Short-chain fatty acids (SCFA) are produced in large amounts in the colon through bacterial fermentation of dietary fiber. We evaluate in mice and in patients treated with anti-CTLA-4 blocking mAbs whether SCFA levels is related to clinical outcome. High blood butyrate and propionate levels are associated with resistance to CTLA-4 blockade and higher proportion of Treg cells. In mice, butyrate restrains anti-CTLA-4-induced up-regulation of CD80/CD86 on dendritic cells and ICOS on T cells, accumulation of tumor-specific T cells and memory T cells. In patients, high blood butyrate levels moderate ipilimumab-induced accumulation of memory and ICOS + CD4 + T cells and IL-2 impregnation. Altogether, these results suggest that SCFA limits anti-CTLA-4 activity.</jats:p>
  • Zugangsstatus: Freier Zugang