> Detailanzeige

Landau, Heather J.; Yellapantula, Venkata; Diamond, Benjamin T.; Rustad, Even H.; Maclachlan, Kylee H.; Gundem, Gunes; Medina-Martinez, Juan; Ossa, Juan Arango; Levine, Max F.; Zhou, Yangyu; Kappagantula, Rajya; Baez, Priscilla; Attiyeh, Marc; Makohon-Moore, Alvin; Zhang, Lance; Boyle, Eileen M.; Ashby, Cody; Blaney, Patrick; Patel, Minal; Zhang, Yanming; Dogan, Ahmet; Chung, David J.; Giralt, Sergio; Lahoud, Oscar B.; [...]

Accelerated single cell seeding in relapsed multiple myeloma

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Accelerated single cell seeding in relapsed multiple myeloma
  • Beteiligte: Landau, Heather J.; Yellapantula, Venkata; Diamond, Benjamin T.; Rustad, Even H.; Maclachlan, Kylee H.; Gundem, Gunes; Medina-Martinez, Juan; Ossa, Juan Arango; Levine, Max F.; Zhou, Yangyu; Kappagantula, Rajya; Baez, Priscilla; Attiyeh, Marc; Makohon-Moore, Alvin; Zhang, Lance; Boyle, Eileen M.; Ashby, Cody; Blaney, Patrick; Patel, Minal; Zhang, Yanming; Dogan, Ahmet; Chung, David J.; Giralt, Sergio; Lahoud, Oscar B.; [...]
  • Erschienen: Springer Science and Business Media LLC, 2020
  • Erschienen in: Nature Communications
  • Sprache: Englisch
  • DOI: 10.1038/s41467-020-17459-z
  • ISSN: 2041-1723
  • Schlagwörter: General Physics and Astronomy ; General Biochemistry, Genetics and Molecular Biology ; General Chemistry ; Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Multiple myeloma (MM) progression is characterized by the seeding of cancer cells in different anatomic sites. To characterize this evolutionary process, we interrogated, by whole genome sequencing, 25 samples collected at autopsy from 4 patients with relapsed MM and an additional set of 125 whole exomes collected from 51 patients. Mutational signatures analysis showed how cytotoxic agents introduce hundreds of unique mutations in each surviving cancer cell, detectable by bulk sequencing only in cases of clonal expansion of a single cancer cell bearing the mutational signature. Thus, a unique, single-cell genomic barcode can link chemotherapy exposure to a discrete time window in a patient′s life. We leveraged this concept to show that MM systemic seeding is accelerated at relapse and appears to be driven by the survival and subsequent expansion of a single myeloma cell following treatment with high-dose melphalan therapy and autologous stem cell transplant.</jats:p>
  • Zugangsstatus: Freier Zugang