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Zabelskii, Dmitrii; Alekseev, Alexey; Kovalev, Kirill; Rankovic, Vladan; Balandin, Taras; Soloviov, Dmytro; Bratanov, Dmitry; Savelyeva, Ekaterina; Podolyak, Elizaveta; Volkov, Dmytro; Vaganova, Svetlana; Astashkin, Roman; Chizhov, Igor; Yutin, Natalia; Rulev, Maksim; Popov, Alexander; Eria-Oliveira, Ana-Sofia; Rokitskaya, Tatiana; Mager, Thomas; Antonenko, Yuri; Rosselli, Riccardo; Armeev, Grigoriy; Shaitan, Konstantin; Vivaudou, Michel; [...]

Viral rhodopsins 1 are an unique family of light-gated cation channels

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  • Medientyp: E-Artikel
  • Titel: Viral rhodopsins 1 are an unique family of light-gated cation channels
  • Beteiligte: Zabelskii, Dmitrii; Alekseev, Alexey; Kovalev, Kirill; Rankovic, Vladan; Balandin, Taras; Soloviov, Dmytro; Bratanov, Dmitry; Savelyeva, Ekaterina; Podolyak, Elizaveta; Volkov, Dmytro; Vaganova, Svetlana; Astashkin, Roman; Chizhov, Igor; Yutin, Natalia; Rulev, Maksim; Popov, Alexander; Eria-Oliveira, Ana-Sofia; Rokitskaya, Tatiana; Mager, Thomas; Antonenko, Yuri; Rosselli, Riccardo; Armeev, Grigoriy; Shaitan, Konstantin; Vivaudou, Michel; [...]
  • Erschienen: Springer Science and Business Media LLC, 2020
  • Erschienen in: Nature Communications
  • Sprache: Englisch
  • DOI: 10.1038/s41467-020-19457-7
  • ISSN: 2041-1723
  • Schlagwörter: General Physics and Astronomy ; General Biochemistry, Genetics and Molecular Biology ; General Chemistry ; Multidisciplinary
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Phytoplankton is the base of the marine food chain as well as oxygen and carbon cycles and thus plays a global role in climate and ecology. Nucleocytoplasmic Large DNA Viruses that infect phytoplankton organisms and regulate the phytoplankton dynamics encompass genes of rhodopsins of two distinct families. Here, we present a functional and structural characterization of two proteins of viral rhodopsin group 1, OLPVR1 and VirChR1. Functional analysis of VirChR1 shows that it is a highly selective, Na<jats:sup>+</jats:sup>/K<jats:sup>+</jats:sup>-conducting channel and, in contrast to known cation channelrhodopsins, it is impermeable to Ca<jats:sup>2+</jats:sup> ions. We show that, upon illumination, VirChR1 is able to drive neural firing. The 1.4 Å resolution structure of OLPVR1 reveals remarkable differences from the known channelrhodopsins and a unique ion-conducting pathway. Thus, viral rhodopsins 1 represent a unique, large group of light-gated channels (viral channelrhodopsins, VirChR1s). In nature, VirChR1s likely mediate phototaxis of algae enhancing the host anabolic processes to support virus reproduction, and therefore, might play a major role in global phytoplankton dynamics. Moreover, VirChR1s have unique potential for optogenetics as they lack possibly noxious Ca<jats:sup>2+</jats:sup> permeability.</jats:p>
  • Zugangsstatus: Freier Zugang