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Ong, Jue-Sheng; Dixon-Suen, Suzanne C.; Han, Xikun; An, Jiyuan; Fitzgerald, Rebecca; Buas, Matt; Gammon, Marilie D.; Corley, Douglas A.; Shaheen, Nicholas J.; Hardie, Laura J.; Bird, Nigel C.; Reid, Brian J.; Chow, Wong-Ho; Risch, Harvey A.; Ye, Weimin; Liu, Geoffrey; Romero, Yvonne; Bernstein, Leslie; Wu, Anna H.; Whiteman, David E.; Vaughan, Thomas; Agee, M.; Alipanahi, B.; Auton, A.; [...]

A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization

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  • Medientyp: E-Artikel
  • Titel: A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization
  • Beteiligte: Ong, Jue-Sheng; Dixon-Suen, Suzanne C.; Han, Xikun; An, Jiyuan; Fitzgerald, Rebecca; Buas, Matt; Gammon, Marilie D.; Corley, Douglas A.; Shaheen, Nicholas J.; Hardie, Laura J.; Bird, Nigel C.; Reid, Brian J.; Chow, Wong-Ho; Risch, Harvey A.; Ye, Weimin; Liu, Geoffrey; Romero, Yvonne; Bernstein, Leslie; Wu, Anna H.; Whiteman, David E.; Vaughan, Thomas; Agee, M.; Alipanahi, B.; Auton, A.; [...]
  • Erschienen: Springer Science and Business Media LLC, 2021
  • Erschienen in: Nature Communications
  • Sprache: Englisch
  • DOI: 10.1038/s41467-020-20368-w
  • ISSN: 2041-1723
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Previous Mendelian randomization (MR) studies on 25-hydroxyvitamin D (25(OH)D) and cancer have typically adopted a handful of variants and found no relationship between 25(OH)D and cancer; however, issues of horizontal pleiotropy cannot be reliably addressed. Using a larger set of variants associated with 25(OH)D (74 SNPs, up from 6 previously), we perform a unified MR analysis to re-evaluate the relationship between 25(OH)D and ten cancers. Our findings are broadly consistent with previous MR studies indicating no relationship, apart from ovarian cancers (OR 0.89; 95% C.I: 0.82 to 0.96 per 1 SD change in 25(OH)D concentration) and basal cell carcinoma (OR 1.16; 95% C.I.: 1.04 to 1.28). However, after adjustment for pigmentation related variables in a multivariable MR framework, the BCC findings were attenuated. Here we report that lower 25(OH)D is unlikely to be a causal risk factor for most cancers, with our study providing more precise confidence intervals than previously possible.</jats:p>
  • Zugangsstatus: Freier Zugang