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Kettwig, Matthias; Ternka, Katharina; Wendland, Kristin; Krüger, Dennis Manfred; Zampar, Silvia; Schob, Charlotte; Franz, Jonas; Aich, Abhishek; Winkler, Anne; Sakib, M. Sadman; Kaurani, Lalit; Epple, Robert; Werner, Hauke B.; Hakroush, Samy; Kitz, Julia; Prinz, Marco; Bartok, Eva; Hartmann, Gunther; Schröder, Simone; Rehling, Peter; Henneke, Marco; Boretius, Susann; Alia, A.; Wirths, Oliver; [...]

Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy

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  • Medientyp: E-Artikel
  • Titel: Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy
  • Beteiligte: Kettwig, Matthias; Ternka, Katharina; Wendland, Kristin; Krüger, Dennis Manfred; Zampar, Silvia; Schob, Charlotte; Franz, Jonas; Aich, Abhishek; Winkler, Anne; Sakib, M. Sadman; Kaurani, Lalit; Epple, Robert; Werner, Hauke B.; Hakroush, Samy; Kitz, Julia; Prinz, Marco; Bartok, Eva; Hartmann, Gunther; Schröder, Simone; Rehling, Peter; Henneke, Marco; Boretius, Susann; Alia, A.; Wirths, Oliver; [...]
  • Erschienen: Springer Science and Business Media LLC, 2021
  • Erschienen in: Nature Communications, 12 (2021) 1
  • Sprache: Englisch
  • DOI: 10.1038/s41467-021-26880-x
  • ISSN: 2041-1723
  • Schlagwörter: General Physics and Astronomy ; General Biochemistry, Genetics and Molecular Biology ; General Chemistry ; Multidisciplinary
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Infantile-onset RNaseT2 deficient leukoencephalopathy is characterised by cystic brain lesions, multifocal white matter alterations, cerebral atrophy, and severe psychomotor impairment. The phenotype is similar to congenital cytomegalovirus brain infection and overlaps with type I interferonopathies, suggesting a role for innate immunity in its pathophysiology. To date, pathophysiological studies have been hindered by the lack of mouse models recapitulating the neuroinflammatory encephalopathy found in patients. In this study, we generated <jats:italic>Rnaset2</jats:italic><jats:sup>−/−</jats:sup> mice using CRISPR/Cas9-mediated genome editing. <jats:italic>Rnaset2</jats:italic><jats:sup>−/−</jats:sup> mice demonstrate upregulation of interferon-stimulated genes and concurrent IFNAR1-dependent neuroinflammation, with infiltration of CD8<jats:sup>+</jats:sup> effector memory T cells and inflammatory monocytes into the grey and white matter. Single nuclei RNA sequencing reveals homeostatic dysfunctions in glial cells and neurons and provide important insights into the mechanisms of hippocampal-accentuated brain atrophy and cognitive impairment. The <jats:italic>Rnaset2</jats:italic><jats:sup>−/−</jats:sup> mice may allow the study of CNS damage associated with RNaseT2 deficiency and may be used for the investigation of potential therapies.</jats:p>
  • Zugangsstatus: Freier Zugang