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Roe, James M.; Vidal-Piñeiro, Didac; Sørensen, Øystein; Brandmaier, Andreas M.; Düzel, Sandra; Gonzalez, Hector A.; Kievit, Rogier A.; Knights, Ethan; Kühn, Simone; Lindenberger, Ulman; Mowinckel, Athanasia M.; Nyberg, Lars; Park, Denise C.; Pudas, Sara; Rundle, Melissa M.; Walhovd, Kristine B.; Fjell, Anders M.; Westerhausen, René; Masters, Colin L.; Bush, Ashley I.; Fowler, Christopher; Darby, David; Pertile, Kelly; Restrepo, Carolina; [...]

Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease

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  • Medientyp: E-Artikel
  • Titel: Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease
  • Beteiligte: Roe, James M.; Vidal-Piñeiro, Didac; Sørensen, Øystein; Brandmaier, Andreas M.; Düzel, Sandra; Gonzalez, Hector A.; Kievit, Rogier A.; Knights, Ethan; Kühn, Simone; Lindenberger, Ulman; Mowinckel, Athanasia M.; Nyberg, Lars; Park, Denise C.; Pudas, Sara; Rundle, Melissa M.; Walhovd, Kristine B.; Fjell, Anders M.; Westerhausen, René; Masters, Colin L.; Bush, Ashley I.; Fowler, Christopher; Darby, David; Pertile, Kelly; Restrepo, Carolina; [...]
  • Erschienen: Springer Science and Business Media LLC, 2021
  • Erschienen in: Nature Communications
  • Sprache: Englisch
  • DOI: 10.1038/s41467-021-21057-y
  • ISSN: 2041-1723
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Aging and Alzheimer’s disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown whether continuous age- and AD-related cortical degradation alters cortical asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order cortical regions exhibiting pronounced asymmetry at age ~20 also show progressive asymmetry-loss across the adult lifespan. Hence, accelerated thinning of the (previously) thicker homotopic hemisphere is a feature of aging. This organizational principle showed high consistency across cohorts in the Lifebrain consortium, and both the topological patterns and temporal dynamics of asymmetry-loss were markedly similar across replicating samples. Asymmetry-change was further accelerated in AD. Results suggest a system-wide dedifferentiation of the adaptive asymmetric organization of heteromodal cortex in aging and AD.</jats:p>
  • Zugangsstatus: Freier Zugang