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Huynh-Le, Minh-Phuong; Fan, Chun Chieh; Karunamuni, Roshan; Thompson, Wesley K.; Martinez, Maria Elena; Eeles, Rosalind A.; Kote-Jarai, Zsofia; Muir, Kenneth; Schleutker, Johanna; Pashayan, Nora; Batra, Jyotsna; Grönberg, Henrik; Neal, David E.; Donovan, Jenny L.; Hamdy, Freddie C.; Martin, Richard M.; Nielsen, Sune F.; Nordestgaard, Børge G.; Wiklund, Fredrik; Tangen, Catherine M.; Giles, Graham G.; Wolk, Alicja; Albanes, Demetrius; Travis, Ruth C.; [...]

Polygenic hazard score is associated with prostate cancer in multi-ethnic populations

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  • Medientyp: E-Artikel
  • Titel: Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
  • Beteiligte: Huynh-Le, Minh-Phuong; Fan, Chun Chieh; Karunamuni, Roshan; Thompson, Wesley K.; Martinez, Maria Elena; Eeles, Rosalind A.; Kote-Jarai, Zsofia; Muir, Kenneth; Schleutker, Johanna; Pashayan, Nora; Batra, Jyotsna; Grönberg, Henrik; Neal, David E.; Donovan, Jenny L.; Hamdy, Freddie C.; Martin, Richard M.; Nielsen, Sune F.; Nordestgaard, Børge G.; Wiklund, Fredrik; Tangen, Catherine M.; Giles, Graham G.; Wolk, Alicja; Albanes, Demetrius; Travis, Ruth C.; [...]
  • Erschienen: Springer Science and Business Media LLC, 2021
  • Erschienen in: Nature Communications
  • Sprache: Englisch
  • DOI: 10.1038/s41467-021-21287-0
  • ISSN: 2041-1723
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS<jats:sub>1</jats:sub>) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS<jats:sub>2</jats:sub> (PHS<jats:sub>1</jats:sub>, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS<jats:sub>2</jats:sub> is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p &lt; 10<jats:sup>−180</jats:sup>). Comparing the 80<jats:sup>th</jats:sup>/20<jats:sup>th</jats:sup> PHS<jats:sub>2</jats:sub> percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS<jats:sub>2</jats:sub> risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset.</jats:p>
  • Zugangsstatus: Freier Zugang