> Detailanzeige

Sankhala, Rajeshwer S.; Lal, Kerri G.; Jensen, Jaime L.; Dussupt, Vincent; Mendez-Rivera, Letzibeth; Bai, Hongjun; Wieczorek, Lindsay; Mayer, Sandra V.; Zemil, Michelle; Wagner, Danielle A.; Townsley, Samantha M.; Hajduczki, Agnes; Chang, William C.; Chen, Wei-Hung; Donofrio, Gina C.; Jian, Ningbo; King, Hannah A. D.; Lorang, Cynthia G.; Martinez, Elizabeth J.; Rees, Phyllis A.; Peterson, Caroline E.; Schmidt, Fabian; Hart, Tricia J.; Duso, Debra K.; [...]

Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques
  • Beteiligte: Sankhala, Rajeshwer S.; Lal, Kerri G.; Jensen, Jaime L.; Dussupt, Vincent; Mendez-Rivera, Letzibeth; Bai, Hongjun; Wieczorek, Lindsay; Mayer, Sandra V.; Zemil, Michelle; Wagner, Danielle A.; Townsley, Samantha M.; Hajduczki, Agnes; Chang, William C.; Chen, Wei-Hung; Donofrio, Gina C.; Jian, Ningbo; King, Hannah A. D.; Lorang, Cynthia G.; Martinez, Elizabeth J.; Rees, Phyllis A.; Peterson, Caroline E.; Schmidt, Fabian; Hart, Tricia J.; Duso, Debra K.; [...]
  • Erschienen: Springer Science and Business Media LLC, 2024
  • Erschienen in: Nature Communications
  • Sprache: Englisch
  • DOI: 10.1038/s41467-023-44265-0
  • ISSN: 2041-1723
  • Schlagwörter: General Physics and Astronomy ; General Biochemistry, Genetics and Molecular Biology ; General Chemistry ; Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>The repeat emergence of SARS-CoV-2 variants of concern (VoC) with decreased susceptibility to vaccine-elicited antibodies highlights the need to develop next-generation vaccine candidates that confer broad protection. Here we describe the antibody response induced by the SARS-CoV-2 Spike Ferritin Nanoparticle (SpFN) vaccine candidate adjuvanted with the Army Liposomal Formulation including QS21 (ALFQ) in non-human primates. By isolating and characterizing several monoclonal antibodies directed against the Spike Receptor Binding Domain (RBD), N-Terminal Domain (NTD), or the S2 Domain, we define the molecular recognition of vaccine-elicited cross-reactive monoclonal antibodies (mAbs) elicited by SpFN. We identify six neutralizing antibodies with broad sarbecovirus cross-reactivity that recapitulate serum polyclonal antibody responses. In particular, RBD mAb WRAIR-5001 binds to the conserved cryptic region with high affinity to sarbecovirus clades 1 and 2, including Omicron variants, while mAb WRAIR-5021 offers complete protection from B.1.617.2 (Delta) in a murine challenge study. Our data further highlight the ability of SpFN vaccination to stimulate cross-reactive B cells targeting conserved regions of the Spike with activity against SARS CoV-1 and SARS-CoV-2 variants.</jats:p>
  • Zugangsstatus: Freier Zugang