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Liu, Feng; Gross, F. Liaini; Joshi, Sneha; Gaglani, Manjusha; Naleway, Allison L.; Murthy, Kempapura; Groom, Holly C.; Wesley, Meredith G.; Edwards, Laura J.; Grant, Lauren; Kim, Sara S.; Sambhara, Suryaprakash; Gangappa, Shivaprakash; Tumpey, Terrence; Thompson, Mark G.; Fry, Alicia M.; Flannery, Brendan; Dawood, Fatimah S.; Levine, Min Z.

Redirecting antibody responses from egg-adapted epitopes following repeat vaccination with recombinant or cell culture-based versus egg-based influenza vaccines

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  • Medientyp: E-Artikel
  • Titel: Redirecting antibody responses from egg-adapted epitopes following repeat vaccination with recombinant or cell culture-based versus egg-based influenza vaccines
  • Beteiligte: Liu, Feng; Gross, F. Liaini; Joshi, Sneha; Gaglani, Manjusha; Naleway, Allison L.; Murthy, Kempapura; Groom, Holly C.; Wesley, Meredith G.; Edwards, Laura J.; Grant, Lauren; Kim, Sara S.; Sambhara, Suryaprakash; Gangappa, Shivaprakash; Tumpey, Terrence; Thompson, Mark G.; Fry, Alicia M.; Flannery, Brendan; Dawood, Fatimah S.; Levine, Min Z.
  • Erschienen: Springer Science and Business Media LLC, 2024
  • Erschienen in: Nature Communications
  • Sprache: Englisch
  • DOI: 10.1038/s41467-023-44551-x
  • ISSN: 2041-1723
  • Schlagwörter: General Physics and Astronomy ; General Biochemistry, Genetics and Molecular Biology ; General Chemistry ; Multidisciplinary
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Repeat vaccination with egg-based influenza vaccines could preferentially boost antibodies targeting the egg-adapted epitopes and reduce immunogenicity to circulating viruses. In this randomized trial (Clinicaltrials.gov: NCT03722589), sera pre- and post-vaccination with quadrivalent inactivated egg-based (IIV4), cell culture-based (ccIIV4), and recombinant (RIV4) influenza vaccines were collected from healthcare personnel (18-64 years) in 2018−19 (<jats:italic>N</jats:italic> = 723) and 2019−20 (<jats:italic>N</jats:italic> = 684) influenza seasons. We performed an exploratory analysis. Vaccine egg-adapted changes had the most impact on A(H3N2) immunogenicity. In year 1, RIV4 induced higher neutralizing and total HA head binding antibodies to cell- A(H3N2) virus than ccIIV4 and IIV4. In year 2, among the 7 repeat vaccination arms (IIV4-IIV4, IIV4-ccIIV4, IIV4-RIV4, RIV4-ccIIV4, RIV4-RIV4, ccIIV4-ccIIV4 and ccIIV4-RIV4), repeat vaccination with either RIV4 or ccIIV4 further improved antibody responses to circulating viruses with decreased neutralizing antibody egg/cell ratio. RIV4 also had higher post-vaccination A(H1N1)pdm09 and A(H3N2) HA stalk antibodies in year 1, but there was no significant difference in HA stalk antibody fold rise among vaccine groups in either year 1 or year 2. Multiple seasons of non-egg-based vaccination may be needed to redirect antibody responses from immune memory to egg-adapted epitopes and re-focus the immune responses towards epitopes on the circulating viruses to improve vaccine effectiveness.</jats:p>
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