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Ye, Huimin; Borusak, Sabrina; Eberl, Claudia; Krasenbrink, Julia; Weiss, Anna S.; Chen, Song-Can; Hanson, Buck T.; Hausmann, Bela; Herbold, Craig W.; Pristner, Manuel; Zwirzitz, Benjamin; Warth, Benedikt; Pjevac, Petra; Schleheck, David; Stecher, Bärbel; Loy, Alexander

Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut

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  • Medientyp: E-Artikel
  • Titel: Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut
  • Beteiligte: Ye, Huimin; Borusak, Sabrina; Eberl, Claudia; Krasenbrink, Julia; Weiss, Anna S.; Chen, Song-Can; Hanson, Buck T.; Hausmann, Bela; Herbold, Craig W.; Pristner, Manuel; Zwirzitz, Benjamin; Warth, Benedikt; Pjevac, Petra; Schleheck, David; Stecher, Bärbel; Loy, Alexander
  • Erschienen: Springer Science and Business Media LLC, 2023
  • Erschienen in: Nature Communications
  • Sprache: Englisch
  • DOI: 10.1038/s41467-023-41008-z
  • ISSN: 2041-1723
  • Entstehung:
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Taurine-respiring gut bacteria produce H<jats:sub>2</jats:sub>S with ambivalent impact on host health. We report the isolation and ecophysiological characterization of a taurine-respiring mouse gut bacterium. <jats:italic>Taurinivorans muris</jats:italic> strain LT0009 represents a new widespread species that differs from the human gut sulfidogen <jats:italic>Bilophila wadsworthia</jats:italic> in its sulfur metabolism pathways and host distribution. <jats:italic>T. muris</jats:italic> specializes in taurine respiration in vivo, seemingly unaffected by mouse diet and genotype, but is dependent on other bacteria for release of taurine from bile acids. Colonization of <jats:italic>T. muris</jats:italic> in gnotobiotic mice increased deconjugation of taurine-conjugated bile acids and transcriptional activity of a sulfur metabolism gene-encoding prophage in other commensals, and slightly decreased the abundance of <jats:italic>Salmonella enterica</jats:italic>, which showed reduced expression of galactonate catabolism genes. Re-analysis of metagenome data from a previous study further suggested that <jats:italic>T. muris</jats:italic> can contribute to protection against pathogens by the commensal mouse gut microbiota. Together, we show the realized physiological niche of a key murine gut sulfidogen and its interactions with selected gut microbiota members.</jats:p>
  • Zugangsstatus: Freier Zugang