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Jost, Stefanie T.; Visser-Vandewalle, Veerle; Rizos, Alexandra; Loehrer, Philipp A.; Silverdale, Monty; Evans, Julian; Samuel, Michael; Petry-Schmelzer, Jan Niklas; Sauerbier, Anna; Gronostay, Alexandra; Barbe, Michael T.; Fink, Gereon R.; Ashkan, Keyoumars; Antonini, Angelo; Martinez-Martin, Pablo; Chaudhuri, K. Ray; Timmermann, Lars; Dafsari, Haidar S.; Bhidayasiri, Roongroj; Falup-Pecurariu, Cristian; Jeon, Beomseok; Leta, Valentina; Borghammer, Per; Odin, Per; [...]

Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease

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  • Medientyp: E-Artikel
  • Titel: Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease
  • Beteiligte: Jost, Stefanie T.; Visser-Vandewalle, Veerle; Rizos, Alexandra; Loehrer, Philipp A.; Silverdale, Monty; Evans, Julian; Samuel, Michael; Petry-Schmelzer, Jan Niklas; Sauerbier, Anna; Gronostay, Alexandra; Barbe, Michael T.; Fink, Gereon R.; Ashkan, Keyoumars; Antonini, Angelo; Martinez-Martin, Pablo; Chaudhuri, K. Ray; Timmermann, Lars; Dafsari, Haidar S.; Bhidayasiri, Roongroj; Falup-Pecurariu, Cristian; Jeon, Beomseok; Leta, Valentina; Borghammer, Per; Odin, Per; [...]
  • Erschienen: Springer Science and Business Media LLC, 2021
  • Erschienen in: npj Parkinson's Disease, 7 (2021) 1
  • Sprache: Englisch
  • DOI: 10.1038/s41531-021-00174-x
  • ISSN: 2373-8057
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: AbstractTo identify predictors of 36-month follow-up quality of life (QoL) outcome after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s disease (PD). In this ongoing, prospective, multicenter international study (Cologne, Manchester, London) including 73 patients undergoing STN-DBS, we assessed the following scales preoperatively and at 6-month and 36-month follow-up: PD Questionnaire-8 (PDQ-8), NMSScale (NMSS), Scales for Outcomes in PD (SCOPA)-motor examination, -activities of daily living, and -complications, and levodopa equivalent daily dose (LEDD). We analyzed factors associated with QoL improvement at 36-month follow-up based on (1) correlations between baseline test scores and QoL improvement, (2) step-wise linear regressions with baseline test scores as independent and QoL improvement as dependent variables, (3) logistic regressions and receiver operating characteristic curves using a dichotomized variable “QoL responders”/“non-responders”. At both follow-ups, NMSS total score, SCOPA-motor examination, and -complications improved and LEDD was reduced significantly. PDQ-8 improved at 6-month follow-up with subsequent decrements in gains at 36-month follow-up when 61.6% of patients were categorized as “QoL non-responders”. Correlations, linear, and logistic regression analyses found greater PDQ-8 improvements in patients with younger age, worse PDQ-8, and worse specific NMS at baseline, such as ‘difficulties experiencing pleasure’ and ‘problems sustaining concentration’. Baseline SCOPA scores were not associated with PDQ-8 changes. Our results provide evidence that 36-month QoL changes depend on baseline neuropsychological and neuropsychiatric non-motor symptoms burden. These findings highlight the need for an assessment of a wide range of non-motor and motor symptoms when advising and selecting individuals for DBS therapy.
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