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McCracken, Michael K.; Kuklis, Caitlin H.; Kannadka, Chandrika B.; Barvir, David A.; Sanborn, Mark A.; Waickman, Adam T.; Siegfried, Hayden C.; Victor, Kaitlin A.; Hatch, Kristin L.; De La Barrera, Rafael; Walls, Shannon D.; Rutvisuttinunt, Wiriya; Currier, Jeffrey R.; Friberg, Heather; Jarman, Richard G.; Gromowski, Gregory D.

Enhanced dengue vaccine virus replication and neutralizing antibody responses in immune primed rhesus macaques

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  • Medientyp: E-Artikel
  • Titel: Enhanced dengue vaccine virus replication and neutralizing antibody responses in immune primed rhesus macaques
  • Beteiligte: McCracken, Michael K.; Kuklis, Caitlin H.; Kannadka, Chandrika B.; Barvir, David A.; Sanborn, Mark A.; Waickman, Adam T.; Siegfried, Hayden C.; Victor, Kaitlin A.; Hatch, Kristin L.; De La Barrera, Rafael; Walls, Shannon D.; Rutvisuttinunt, Wiriya; Currier, Jeffrey R.; Friberg, Heather; Jarman, Richard G.; Gromowski, Gregory D.
  • Erschienen: Springer Science and Business Media LLC, 2021
  • Erschienen in: npj Vaccines
  • Sprache: Englisch
  • DOI: 10.1038/s41541-021-00339-y
  • ISSN: 2059-0105
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Antibody-dependent enhancement (ADE) is suspected to influence dengue virus (DENV) infection, but the role ADE plays in vaccination strategies incorporating live attenuated virus components is less clear. Using a heterologous prime-boost strategy in rhesus macaques, we examine the effect of priming with DENV purified inactivated vaccines (PIVs) on a tetravalent live attenuated vaccine (LAV). Sera exhibited low-level neutralizing antibodies (NAb) post PIV priming, yet moderate to high in vitro ADE activity. Following LAV administration, the PIV primed groups exhibited DENV-2 LAV peak viremias up to 1,176-fold higher than the mock primed group, and peak viremia correlated with in vitro ADE. Furthermore, PIV primed groups had more balanced and higher DENV-1–4 NAb seroconversion and titers than the mock primed group following LAV administration. These results have implications for the development of effective DENV vaccine prime-boost strategies and for our understanding of the role played by ADE in modulating DENV replication.</jats:p>
  • Zugangsstatus: Freier Zugang