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Jayakodi, Murukarthick; Padmarasu, Sudharsan; Haberer, Georg; Bonthala, Venkata Suresh; Gundlach, Heidrun; Monat, Cécile; Lux, Thomas; Kamal, Nadia; Lang, Daniel; Himmelbach, Axel; Ens, Jennifer; Zhang, Xiao-Qi; Angessa, Tefera T.; Zhou, Gaofeng; Tan, Cong; Hill, Camilla; Wang, Penghao; Schreiber, Miriam; Boston, Lori B.; Plott, Christopher; Jenkins, Jerry; Guo, Yu; Fiebig, Anne; Budak, Hikmet; [...]

The barley pan-genome reveals the hidden legacy of mutation breeding

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  • Medientyp: E-Artikel
  • Titel: The barley pan-genome reveals the hidden legacy of mutation breeding
  • Beteiligte: Jayakodi, Murukarthick; Padmarasu, Sudharsan; Haberer, Georg; Bonthala, Venkata Suresh; Gundlach, Heidrun; Monat, Cécile; Lux, Thomas; Kamal, Nadia; Lang, Daniel; Himmelbach, Axel; Ens, Jennifer; Zhang, Xiao-Qi; Angessa, Tefera T.; Zhou, Gaofeng; Tan, Cong; Hill, Camilla; Wang, Penghao; Schreiber, Miriam; Boston, Lori B.; Plott, Christopher; Jenkins, Jerry; Guo, Yu; Fiebig, Anne; Budak, Hikmet; [...]
  • Erschienen: Springer Science and Business Media LLC, 2020
  • Erschienen in: Nature
  • Sprache: Englisch
  • DOI: 10.1038/s41586-020-2947-8
  • ISSN: 1476-4687; 0028-0836
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Genetic diversity is key to crop improvement. Owing to pervasive genomic structural variation, a single reference genome assembly cannot capture the full complement of sequence diversity of a crop species (known as the ‘pan-genome’<jats:sup>1</jats:sup>). Multiple high-quality sequence assemblies are an indispensable component of a pan-genome infrastructure. Barley (<jats:italic>Hordeum vulgare</jats:italic> L.) is an important cereal crop with a long history of cultivation that is adapted to a wide range of agro-climatic conditions<jats:sup>2</jats:sup>. Here we report the construction of chromosome-scale sequence assemblies for the genotypes of 20 varieties of barley—comprising landraces, cultivars and a wild barley—that were selected as representatives of global barley diversity. We catalogued genomic presence/absence variants and explored the use of structural variants for quantitative genetic analysis through whole-genome shotgun sequencing of 300 gene bank accessions. We discovered abundant large inversion polymorphisms and analysed in detail two inversions that are frequently found in current elite barley germplasm; one is probably the product of mutation breeding and the other is tightly linked to a locus that is involved in the expansion of geographical range. This first-generation barley pan-genome makes previously hidden genetic variation accessible to genetic studies and breeding.</jats:p>