> Detailanzeige

Vorperian, Sevahn K.; Moufarrej, Mira N.; Jones, Robert C.; Karkanias, Jim; Krasnow, Mark; Pisco, Angela Oliveira; Quake, Stephen R.; Salzman, Julia; Yosef, Nir; Bulthaup, Bryan; Brown, Phillip; Harper, William; Hemenez, Marisa; Ponnusamy, Ravikumar; Salehi, Ahmad; Sanagavarapu, Bhavani A.; Spallino, Eileen; Aaron, Ksenia A.; Concepcion, Waldo; Gardner, James M.; Kelly, Burnett; Neidlinger, Nikole; Wang, Zifa; Crasta, Sheela; [...]

Cell types of origin of the cell-free transcriptome

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Cell types of origin of the cell-free transcriptome
  • Beteiligte: Vorperian, Sevahn K.; Moufarrej, Mira N.; Jones, Robert C.; Karkanias, Jim; Krasnow, Mark; Pisco, Angela Oliveira; Quake, Stephen R.; Salzman, Julia; Yosef, Nir; Bulthaup, Bryan; Brown, Phillip; Harper, William; Hemenez, Marisa; Ponnusamy, Ravikumar; Salehi, Ahmad; Sanagavarapu, Bhavani A.; Spallino, Eileen; Aaron, Ksenia A.; Concepcion, Waldo; Gardner, James M.; Kelly, Burnett; Neidlinger, Nikole; Wang, Zifa; Crasta, Sheela; [...]
  • Erschienen: Springer Science and Business Media LLC, 2022
  • Erschienen in: Nature Biotechnology
  • Sprache: Englisch
  • DOI: 10.1038/s41587-021-01188-9
  • ISSN: 1087-0156; 1546-1696
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases in combination with the Human Protein Atlas RNA consensus dataset. We define cell type signature scores, which allow the inference of cell types that contribute to cell-free RNA for a variety of diseases.</jats:p>