• Medientyp: E-Artikel
  • Titel: Organ Mapping Antibody Panels: a community resource for standardized multiplexed tissue imaging
  • Beteiligte: Quardokus, Ellen M.; Saunders, Diane C.; McDonough, Elizabeth; Hickey, John W.; Werlein, Christopher; Surrette, Christine; Rajbhandari, Presha; Casals, Anna Martinez; Tian, Hua; Lowery, Lisa; Neumann, Elizabeth K.; Björklund, Frida; Neelakantan, Taruna V.; Croteau, Josh; Wiblin, Anne E.; Fisher, Jeremy; Livengood, April J.; Dowell, Karen G.; Silverstein, Jonathan C.; Spraggins, Jeffrey M.; Pryhuber, Gloria S.; Deutsch, Gail; Ginty, Fiona; Nolan, Garry P.; [...]
  • Erschienen: Springer Science and Business Media LLC, 2023
  • Erschienen in: Nature Methods, 20 (2023) 8, Seite 1174-1178
  • Sprache: Englisch
  • DOI: 10.1038/s41592-023-01846-7
  • ISSN: 1548-7091; 1548-7105
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Multiplexed antibody-based imaging enables the detailed characterization of molecular and cellular organization in tissues. Advances in the field now allow high-parameter data collection (&gt;60 targets); however, considerable expertise and capital are needed to construct the antibody panels employed by these methods. Organ mapping antibody panels are community-validated resources that save time and money, increase reproducibility, accelerate discovery and support the construction of a Human Reference Atlas.</jats:p>