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Verheijen, Marcha; Sarkans, Ugis; Wolski, Witold; Jennen, Danyel; Caiment, Florian; Kleinjans, Jos; Agarkova, Irina; Atkinson, Francis L.; Bachmann, Ivo; Baier, Vanessa; Barel, Gal; Bauer, Chris; van den Beucken, Twan; Boerno, Stefan; Bosc, Nicolas; Carey, Conn; Castell, José V.; Clayton, Olivia; Cordes, Henrik; Deeb, Sally; Gmuender, Hans; Gotta, Stefano; Guye, Patrick; Hersey, Anne; [...]

Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds

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  • Medientyp: E-Artikel
  • Titel: Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds
  • Beteiligte: Verheijen, Marcha; Sarkans, Ugis; Wolski, Witold; Jennen, Danyel; Caiment, Florian; Kleinjans, Jos; Agarkova, Irina; Atkinson, Francis L.; Bachmann, Ivo; Baier, Vanessa; Barel, Gal; Bauer, Chris; van den Beucken, Twan; Boerno, Stefan; Bosc, Nicolas; Carey, Conn; Castell, José V.; Clayton, Olivia; Cordes, Henrik; Deeb, Sally; Gmuender, Hans; Gotta, Stefano; Guye, Patrick; Hersey, Anne; [...]
  • Erschienen: Springer Science and Business Media LLC, 2022
  • Erschienen in: Scientific Data
  • Sprache: Englisch
  • DOI: 10.1038/s41597-022-01825-1
  • ISSN: 2052-4463
  • Schlagwörter: Library and Information Sciences ; Statistics, Probability and Uncertainty ; Computer Science Applications ; Education ; Information Systems ; Statistics and Probability
  • Entstehung:
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>The data currently described was generated within the EU/FP7 HeCaToS project (<jats:bold><jats:underline>He</jats:underline></jats:bold>patic and<jats:bold><jats:underline>Ca</jats:underline></jats:bold>rdiac<jats:bold><jats:underline>To</jats:underline></jats:bold>xicity<jats:bold><jats:underline>S</jats:underline></jats:bold>ystems modeling). The project aimed to develop an<jats:italic>in silico</jats:italic>prediction system to contribute to drug safety assessment for humans. For this purpose, multi-omics data of repeated dose toxicity were obtained for 10 hepatotoxic and 10 cardiotoxic compounds. Most data were gained from<jats:italic>in vitro</jats:italic>experiments in which 3D microtissues (either hepatic or cardiac) were exposed to a therapeutic (physiologically relevant concentrations calculated through PBPK-modeling) or a toxic dosing profile (IC20 after 7 days). Exposures lasted for 14 days and samples were obtained at 7 time points (therapeutic doses: 2-8-24-72-168-240-336 h; toxic doses 0-2-8-24-72-168-240 h). Transcriptomics (RNA sequencing &amp; microRNA sequencing), proteomics (LC-MS), epigenomics (MeDIP sequencing) and metabolomics (LC-MS &amp; NMR) data were obtained from these samples. Furthermore, functional endpoints (ATP content, Caspase3/7 and O2 consumption) were measured in exposed microtissues. Additionally, multi-omics data from human biopsies from patients are available. This data is now being released to the scientific community through the BioStudies data repository (<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="https://www.ebi.ac.uk/biostudies/">https://www.ebi.ac.uk/biostudies/</jats:ext-link>).</jats:p>
  • Zugangsstatus: Freier Zugang