Beschreibung:
<jats:title>Abstract</jats:title><jats:p>Diagnosis of sleep apnea (SA) using simple tools has the potential to improve the efficacy of cardiac implants in the prevention of cardiac arrhythmias. The aim of the present study was to validate a transthoracic impedance sensor for SA diagnosis in patients with cardiac implants. We compared the apnea-hypopnea index (AHI) obtained from polysomnography (AHI<jats:sub>PSG</jats:sub>) with the AHI obtained from autoscoring algorithms of the ApneaScan implantable impedance respiration sensor (AHI<jats:sub>AS</jats:sub>) three months after implantation of cardioverter-defibrillator (ICD) or cardiac resynchronization therapy-defibrillator (CRT-D) devices. Twenty-five patients with indications for implantation of ICD or CRT-D (INCEPTA; Boston Scientific) (24 men, 59.9 ± 14.4 years; LVEF 30.3 ± 6.4%; body mass index 25.9 ± 4.2 kg/m²) were included. Mean AHI-<jats:sub>PSG</jats:sub> was 21.9 ± 19.1 events/hr. A significant correlation was found between AHI<jats:sub>PSG</jats:sub> and AHI<jats:sub>AS</jats:sub> especially for the most severe SA (Spearman correlation: 0.71, p < 0.001). Intraclass Correlation Coefficient (was in the expected range: 0.67, 95% CI: 0.39–0.84. The mean bias was 5.4 events per hour (mean AHI: 23.3 ± 14.6 versus 29.7 ± 13.7 for AHI-<jats:sub>PSG</jats:sub> and AHI-<jats:sub>AS,</jats:sub> respectively). An optimal cutoff value for the AHI<jats:sub>AS</jats:sub> at 30 events/h was obtained from the Receiver Operator Characteristic (ROC) curve analysis, which yielded a sensitivity of 100%, a specificity of 80%, PPV = 67%, NPV = 100%. Using an advanced algorithm for autoscoring of transthoracic impedance included in ICDs is reliable to identify SA and has the potential to improve the management of patients with cardiac implants.</jats:p>