Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Differentiating external zeitgeber impact on peripheral circadian clock resetting
Beteiligte:
Heyde, Isabel;
Oster, Henrik
Erschienen:
Springer Science and Business Media LLC, 2019
Erschienen in:
Scientific Reports, 9 (2019) 1
Sprache:
Englisch
DOI:
10.1038/s41598-019-56323-z
ISSN:
2045-2322
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title><jats:p>Circadian clocks regulate physiological functions, including energy metabolism, along the 24-hour day cycle. The mammalian clock system is organized in a hierarchical manner with a coordinating pacemaker residing in the hypothalamic suprachiasmatic nucleus (SCN). The SCN clock is reset primarily by the external light-dark cycle while other <jats:italic>zeitgebers</jats:italic> such as the timing of food intake are potent synchronizers of many peripheral tissue clocks. Under conflicting <jats:italic>zeitgeber</jats:italic> conditions, e.g. during shift work, phase synchrony across the clock network is disrupted promoting the development of metabolic disorders. We established a <jats:italic>zeitgeber</jats:italic> desynchrony (ZD) paradigm to quantify the differential contributions of the two main <jats:italic>zeitgebers</jats:italic>, light and food, to the resetting of specific tissue clocks and the effect on metabolic homeostasis in mice. Under 28-hour light-dark and 24-hour feeding-fasting conditions SCN and peripheral clock, as well as activity and hormonal rhythms showed specific periodicities aligning in-between those of the two <jats:italic>zeitgebers</jats:italic>. During ZD, metabolic homeostasis was cyclic with mice gaining weight under synchronous and losing weight under conflicting <jats:italic>zeitgeber</jats:italic> conditions. In summary, our study establishes an experimental paradigm to compare <jats:italic>zeitgeber</jats:italic> input <jats:italic>in vivo</jats:italic> and study the physiological consequences of chronodisruption.</jats:p>