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Abdelaziz Abdelmoneim, Shaimaa; Mohamed Ghazy, Ramy; Anwar Sultan, Eman; Hassaan, Mahmoud A.; Anwar Mahgoub, Mohamed

Antimicrobial resistance burden pre and post-COVID-19 pandemic with mapping the multidrug resistance in Egypt: a comparative cross-sectional study

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  • Medientyp: E-Artikel
  • Titel: Antimicrobial resistance burden pre and post-COVID-19 pandemic with mapping the multidrug resistance in Egypt: a comparative cross-sectional study
  • Beteiligte: Abdelaziz Abdelmoneim, Shaimaa; Mohamed Ghazy, Ramy; Anwar Sultan, Eman; Hassaan, Mahmoud A.; Anwar Mahgoub, Mohamed
  • Erschienen: Springer Science and Business Media LLC, 2024
  • Erschienen in: Scientific Reports
  • Sprache: Englisch
  • DOI: 10.1038/s41598-024-56254-4
  • ISSN: 2045-2322
  • Schlagwörter: Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Overuse of antibiotics during coronavirus disease 2019 (COVID-19) in an attempt to reduce COVID-19 mortality in the short term may have contributed to long-term mortality from antimicrobial resistance (AMR). The aim of this study was to evaluate the impact of the COVID-19 pandemic on AMR in Egypt and map the distribution of multidrug-resistant (MDR) and extensive drug-resistant (XDR) across Egypt. Through a multicenter cross-sectional study 2430 culture results were collected in 2019 and 2022 pre and post-COVID-19 pandemic in Egypt, including 400 <jats:italic>Klebsiella pneumoniae,</jats:italic> 760 <jats:italic>Escherichia coli</jats:italic>, 650 <jats:italic>Acinetobacter baumannii</jats:italic>, and 620 <jats:italic>Methicillin-resistant</jats:italic><jats:italic>staphylococcus </jats:italic><jats:italic>aureus</jats:italic> (MRSA) culture results. MDR and XDR culture results distribution across Egypt was highlighted through the geographic information system. Mixed effect logistic regression models and sub-group analysis were performed according to the type of specimens to test the impact of COVID-19 on resistance. Adjusted analysis demonstrated <jats:italic>K. pneumoniae</jats:italic> resistance has increased against quinolones and carbapenems (<jats:italic>P</jats:italic> &lt; 0.001). Resistance of <jats:italic>E. coli</jats:italic> has increased significantly against imipenem and meropenem. While <jats:italic>E.coli</jats:italic> susceptibility has increased to cefoxitin, levofloxacin, and ciprofloxacin. <jats:italic>A. baumannii</jats:italic> resistance has increased more than double against ceftazidime, cefepime, and piperacillin-tazobactam (<jats:italic>P</jats:italic> &lt; 0.001). MRSA reserved its susceptibility to vancomycin and linezolid. MDR <jats:italic>K. pneumoniae</jats:italic> and <jats:italic>A. baumannii</jats:italic> have increased post-COVID-19 from 67% to 94% and from 79% to 98%, respectively (<jats:italic>P</jats:italic> &lt; 0.001). XDR <jats:italic>K. pneumoniae</jats:italic> and <jats:italic>A. baumannii</jats:italic> have increased from 6% to 46%, and from 47% to 69%, respectively (<jats:italic>P</jats:italic> &lt; 0.001). COVID-19 has changed the profile of AMR in Egypt so that urgent action is required to mitigate this threat and preserve our capacity to face infections in future decades.</jats:p>
  • Zugangsstatus: Freier Zugang