• Medientyp: E-Artikel
  • Titel: Setting a baseline for global urban virome surveillance in sewage
  • Beteiligte: Nieuwenhuijse, David F.; Oude Munnink, Bas B.; Phan, My V. T.; Hendriksen, Rene S.; Bego, Artan; Rees, Catherine; Neilson, Elizabeth Heather; Coventry, Kris; Collignon, Peter; Allerberger, Franz; Rahube, Teddie O.; Oliveira, Guilherme; Ivanov, Ivan; Sopheak, Thet; Vuthy, Yith; Yost, Christopher K.; Tabo, Djim-adjim; Cuadros-Orellana, Sara; Ke, Changwen; Zheng, Huanying; Baisheng, Li; Jiao, Xiaoyang; Donado-Godoy, Pilar; Coulibaly, Kalpy Julien; [...]
  • Erschienen: Springer Science and Business Media LLC, 2020
  • Erschienen in: Scientific Reports
  • Sprache: Englisch
  • DOI: 10.1038/s41598-020-69869-0
  • ISSN: 2045-2322
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>The rapid development of megacities, and their growing connectedness across the world is becoming a distinct driver for emerging disease outbreaks. Early detection of unusual disease emergence and spread should therefore include such cities as part of risk-based surveillance. A catch-all metagenomic sequencing approach of urban sewage could potentially provide an unbiased insight into the dynamics of viral pathogens circulating in a community irrespective of access to care, a potential which already has been proven for the surveillance of poliovirus. Here, we present a detailed characterization of sewage viromes from a snapshot of 81 high density urban areas across the globe, including in-depth assessment of potential biases, as a proof of concept for catch-all viral pathogen surveillance. We show the ability to detect a wide range of viruses and geographical and seasonal differences for specific viral groups. Our findings offer a cross-sectional baseline for further research in viral surveillance from urban sewage samples and place previous studies in a global perspective.</jats:p>
  • Zugangsstatus: Freier Zugang